Liao Po-Hao, Lin Yu-Chun, Chu Cheng-Hsin, Shih Shou-Chuan, Liou Tai-Cherng
Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital New Taipei Taiwan.
Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan.
JGH Open. 2018 May 15;2(3):93-96. doi: 10.1002/jgh3.12053. eCollection 2018 Jun.
To assess the detection rates of colonization in the gastric cardia with two commercial kits of rapid urease test: 5 min UFT300 and 24 h CLO test in H. pylori-infected patients.
Eighty consecutive dyspeptic patients with confirmed H. pylori infection (serology and C-urea breath test) were prospectively studied. During endoscopy, tissue samples using separate biopsy forceps from the cardia were taken for the UFT300 and CLO tests. The results of the UFT300 were read at 5 and 30 min, and those of the CLO test were read at 24 h.
Of 80 enrolled patients, 17 (21.3%) and 44 (55%) had positive findings with the UFT300 at 5 and 30 min, respectively, while 72 (90%) had positive findings with the CLO test at 24 h. The CLO test is significantly more sensitive than the UFT300 in evaluating H. pylori status in the cardia. On comparing patients with and without carditis, the detection rates of the CLO test were similar (91.1% 88.6%; = 0.724), and the rates of the UFT300 were also similar at 5 and 30 min.
The rate of H. pylori colonization in the gastric cardia was 90% in H. pylori-infected patients detected with the CLO test. Although the UFT300 provides a more rapid reading of H. pylori status, the diagnostic yield of the CLO test is much higher than that of the UFT300. However, a positive result of the UFT300 may indicate a higher bacterial load in the cardia, which warrants a more effective therapeutic strategy.
使用两种快速尿素酶检测商业试剂盒（5分钟UFT300和24小时CLO检测）评估幽门螺杆菌感染患者胃贲门部的定植检出率。
对80例经确诊幽门螺杆菌感染（血清学和碳-尿素呼气试验）的连续消化不良患者进行前瞻性研究。在内镜检查期间，使用单独的活检钳从贲门部获取组织样本进行UFT300和CLO检测。UFT300的结果在5分钟和30分钟时读取，CLO检测的结果在24小时时读取。
在80例入组患者中，UFT300在5分钟和30分钟时分别有17例（21.3%）和44例（55%）呈阳性结果，而CLO检测在24小时时有72例（90%）呈阳性结果。在评估贲门部幽门螺杆菌状态方面，CLO检测比UFT300显著更敏感。比较有和没有贲门炎的患者，CLO检测的检出率相似（91.1%对88.6%；P = 0.724），UFT300在5分钟和30分钟时的检出率也相似。
在通过CLO检测确诊的幽门螺杆菌感染患者中，胃贲门部幽门螺杆菌定植率为90%。尽管UFT300能更快读取幽门螺杆菌状态，但CLO检测的诊断阳性率远高于UFT300。然而，UFT300的阳性结果可能表明贲门部细菌载量更高，这需要更有效的治疗策略。
