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Price of disorder in the lac repressor hinge helix.乳糖阻遏物铰链螺旋中无序状态的代价。
Biopolymers. 2019 Jan;110(1):e23239. doi: 10.1002/bip.23239. Epub 2018 Nov 28.
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The lac repressor hinge helix in context: The effect of the DNA binding domain and symmetry.结合上下文看 lac 阻遏物铰链螺旋：DNA 结合域和对称的影响。
Biochim Biophys Acta Gen Subj. 2020 Apr;1864(4):129538. doi: 10.1016/j.bbagen.2020.129538. Epub 2020 Jan 17.
3
The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator.与对称的乳糖操纵基因结合的乳糖阻遏蛋白头部结构域62的溶液结构。
Structure. 1999 Dec 15;7(12):1483-92. doi: 10.1016/s0969-2126(00)88339-2.
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Altering residues N125 and D149 impacts sugar effector binding and allosteric parameters in Escherichia coli lactose repressor.改变残基 N125 和 D149 会影响大肠杆菌乳糖阻遏物中糖效应物的结合和别构参数。
Biochemistry. 2011 Oct 25;50(42):9002-13. doi: 10.1021/bi200896t. Epub 2011 Sep 30.
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Hinge-helix formation and DNA bending in various lac repressor-operator complexes.各种乳糖阻遏物-操纵基因复合物中的铰链螺旋形成与DNA弯曲
EMBO J. 1999 Nov 15;18(22):6472-80. doi: 10.1093/emboj/18.22.6472.
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Lactose repressor hinge domain independently binds DNA.乳糖阻遏物铰链结构域能独立地结合 DNA。
Protein Sci. 2018 Apr;27(4):839-847. doi: 10.1002/pro.3372. Epub 2018 Feb 16.
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The mechanism and high-free-energy transition state of lac repressor-lac operator interaction.乳糖阻遏蛋白与乳糖操纵基因相互作用的机制及高自由能过渡态
Nucleic Acids Res. 2017 Dec 15;45(22):12671-12680. doi: 10.1093/nar/gkx862.
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Genetic switching by the Lac repressor is based on two-state Monod-Wyman-Changeux allostery.Lac 阻遏物的遗传转换基于二态 Monod-Wyman-Changeux 变构作用。
Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311240120. doi: 10.1073/pnas.2311240120. Epub 2023 Nov 29.
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Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.乳糖操纵子阻遏物及其与DNA和诱导剂复合物的晶体结构。
Science. 1996 Mar 1;271(5253):1247-54. doi: 10.1126/science.271.5253.1247.
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Enhancement of LacI binding in vivo.增强体内 LacI 结合。
Nucleic Acids Res. 2019 Oct 10;47(18):9609-9618. doi: 10.1093/nar/gkz698.
引用本文的文献
1
Simulated pressure changes in LacI suggest a link between hydration and functional conformational changes.模拟 LacI 中的压力变化表明水合作用与功能构象变化之间存在联系。
Biophys Chem. 2024 Jan;304:107126. doi: 10.1016/j.bpc.2023.107126. Epub 2023 Oct 26.
2
Brewing COFFEE: A sequence-specific coarse-grained energy function for simulations of DNA-protein complexes.酿造咖啡：用于DNA-蛋白质复合物模拟的序列特异性粗粒度能量函数。
bioRxiv. 2023 Aug 1:2023.06.07.544064. doi: 10.1101/2023.06.07.544064.
3
The lac repressor hinge helix in context: The effect of the DNA binding domain and symmetry.结合上下文看 lac 阻遏物铰链螺旋：DNA 结合域和对称的影响。
Biochim Biophys Acta Gen Subj. 2020 Apr;1864(4):129538. doi: 10.1016/j.bbagen.2020.129538. Epub 2020 Jan 17.
本文引用的文献
1
Complete Coupled Binding-Folding Pathway of the Intrinsically Disordered Transcription Factor Protein Brinker Revealed by Molecular Dynamics Simulations and Markov State Modeling.分子动力学模拟和马尔可夫状态建模揭示内在无序转录因子蛋白Brinker的完整耦合结合-折叠途径
Biochemistry. 2018 Jul 31;57(30):4404-4420. doi: 10.1021/acs.biochem.8b00441. Epub 2018 Jul 19.
2
Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations.全原子分子动力学模拟研究人胰淀素二聚体在膜环境中的结构特性。
Sci Rep. 2017 Aug 11;7(1):7915. doi: 10.1038/s41598-017-08504-x.
3
Eukaryotic transcription factors: paradigms of protein intrinsic disorder.真核转录因子：蛋白质内在无序的范例
Biochem J. 2017 Jul 12;474(15):2509-2532. doi: 10.1042/BCJ20160631.
4
Free Energy Landscape of Protein-Protein Encounter Resulting from Brownian Dynamics Simulations of Barnase:Barstar.布朗动力学模拟 Barnase:Barstar 蛋白-蛋白碰撞的自由能景观。
J Chem Theory Comput. 2005 Jul;1(4):723-36. doi: 10.1021/ct050036n.
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Solvent effects in the helix-coil transition model can explain the unusual biophysics of intrinsically disordered proteins.螺旋-卷曲转变模型中的溶剂效应可以解释内在无序蛋白质异常的生物物理学特性。
J Chem Phys. 2015 Jul 7;143(1):014102. doi: 10.1063/1.4923292.
6
Force field-dependent solution properties of glycine oligomers.甘氨酸寡聚物的力场依赖性溶液性质。
J Comput Chem. 2015 Jun 30;36(17):1275-85. doi: 10.1002/jcc.23934. Epub 2015 May 7.
7
Recognition mechanism between Lac repressor and DNA with correlation network analysis.通过关联网络分析研究乳糖阻遏物与DNA之间的识别机制。
J Phys Chem B. 2015 Feb 19;119(7):2844-56. doi: 10.1021/jp510940w. Epub 2015 Feb 9.
8
High-resolution specificity from DNA sequencing highlights alternative modes of Lac repressor binding.DNA测序的高分辨率特异性凸显了乳糖阻遏物结合的替代模式。
Genetics. 2014 Nov;198(3):1329-43. doi: 10.1534/genetics.114.170100. Epub 2014 Sep 9.
9
All-atom empirical potential for molecular modeling and dynamics studies of proteins.蛋白质分子建模和动力学研究的全原子经验势。
J Phys Chem B. 1998 Apr 30;102(18):3586-616. doi: 10.1021/jp973084f.
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Coupled folding and binding of the disordered protein PUMA does not require particular residual structure.无序蛋白PUMA的折叠与结合过程并不需要特定的残余结构。
J Am Chem Soc. 2014 Apr 9;136(14):5197-200. doi: 10.1021/ja4125065. Epub 2014 Mar 31.
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