成人社区获得性肺炎住院患者的流感疫苗血清学反应。
Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia.
机构信息
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Influenza Other Respir Viruses. 2019 Mar;13(2):208-212. doi: 10.1111/irv.12622. Epub 2018 Dec 17.
Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.
95 名在社区肺炎病因研究中入组且入院时流感聚合酶链反应（PCR）检测为阴性的成年人在住院期间接受了流感疫苗接种。进行了急性和恢复期流感血清学检测。接种后，甲型 H1N1pdm09、甲型 H3N2、乙型（维多利亚系）和乙型（山形系）流感病毒的血凝抑制抗体滴度（HAI）阳性率分别为 55%、58%、77%和 74%。66 例（69%）患者的血清学转化率（≥4 倍 HAI 升高）≥1 株。未能血清学转化与糖尿病、细菌检测、乙型（山形系）流感的基线阳性血清学滴度以及上一季的流感疫苗接种有关。
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