Key Laboratory of Medical Molecular Virology of MOH and MOE, School of Basic Medical Sciences and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200032, China.
Medical School of Jiaotong University, Shanghai 200025, China.
Cell Rep. 2018 Nov 27;25(9):2379-2389.e3. doi: 10.1016/j.celrep.2018.10.105.
Herpes simplex virus 1 (HSV-1) spreads in populations through a latency entry and reactivation cycle. The role of host immune-suppressive factor regulatory T cells (Treg cells) in controlling latency establishment and reactivation is not completely understood. Here, using an HSV-1 ocular infection murine model, we observe a positive correlation between the level of Treg cells and viral infectivity and demonstrate the requirement for Treg cells in latency establishment. Furthermore, we show that host stress leads to HSV-1 reactivation via increased Treg cell control of CD8 T cells, permitting viral replication under diminished immune surveillance. Together, we propose that Treg cell regulation may serve as a key target for controlling HSV infection.
单纯疱疹病毒 1（HSV-1）通过潜伏进入和再激活循环在人群中传播。宿主免疫抑制因子调节性 T 细胞（Treg 细胞）在控制潜伏建立和再激活中的作用尚未完全阐明。在这里，我们使用 HSV-1 眼部感染的小鼠模型，观察到 Treg 细胞的水平与病毒感染力之间存在正相关，并证明了 Treg 细胞在潜伏建立中的必要性。此外，我们还表明，宿主应激通过增加 Treg 细胞对 CD8 T 细胞的控制导致 HSV-1 再激活，从而在免疫监视减弱的情况下允许病毒复制。总之，我们提出 Treg 细胞的调节可能是控制 HSV 感染的关键靶点。
