γ干扰素可阻止1型单纯疱疹病毒潜伏感染的建立，但对其在小鼠体内的维持或再激活没有影响。
Gamma interferon impedes the establishment of herpes simplex virus type 1 latent infection but has no impact on its maintenance or reactivation in mice.
作者信息
Lekstrom-Himes J A, LeBlanc R A, Pesnicak L, Godleski M, Straus S E
机构信息
Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Virol. 2000 Jul;74(14):6680-3. doi: 10.1128/jvi.74.14.6680-6683.2000.
Abstract
Murine models of gamma interferon (IFN-gamma) deficiency demonstrate the role of this cytokine in attenuating acute herpes simplex virus (HSV) disease; however, the effect of IFN-gamma on the establishment and maintenance of neuronal latency and viral reactivation is not known. Using the IFN-gamma knockout (GKO) model of IFN-gamma deficiency and sensitive quantitative PCR methods, we show that IFN-gamma significantly reduces the ganglion content of latent HSV-1 in BALB/c mice, which in turn delays viral time to reactivation following UV irradiation. Similar effects were not seen in the C57BL/6 strain. These results indicate that IFN-gamma significantly attenuates latent HSV infection in the mouse model of ocular infection but has no impact on the maintenance of latency or virus reactivation.
摘要
γ干扰素（IFN-γ）缺乏的小鼠模型证明了这种细胞因子在减轻急性单纯疱疹病毒（HSV）疾病中的作用；然而，IFN-γ对神经元潜伏状态的建立和维持以及病毒再激活的影响尚不清楚。利用IFN-γ缺乏的IFN-γ基因敲除（GKO）模型和灵敏的定量PCR方法，我们发现IFN-γ显著降低了BALB/c小鼠潜伏HSV-1的神经节含量，这反过来又延迟了紫外线照射后病毒再激活的时间。在C57BL/6品系中未观察到类似的效果。这些结果表明，IFN-γ在眼部感染的小鼠模型中显著减轻潜伏HSV感染，但对潜伏状态的维持或病毒再激活没有影响。
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J Infect Dis. 1999 Sep;180(3):594-9. doi: 10.1086/314962.
2
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J Virol. 1999 Jun;73(6):5196-200. doi: 10.1128/JVI.73.6.5196-5200.1999.
3
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J Virol. 1999 Mar;73(3):1767-73. doi: 10.1128/JVI.73.3.1767-1773.1999.
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5
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J Med Virol. 1998 Oct;56(2):145-50.
6
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7
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