Pereira Thais Cristine, de Barros Patrícia Pimentel, Fugisaki Luciana Ruano de Oliveira, Rossoni Rodnei Dennis, Ribeiro Felipe de Camargo, de Menezes Raquel Teles, Junqueira Juliana Campos, Scorzoni Liliana
Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil.
J Fungi (Basel). 2018 Nov 27;4(4):128. doi: 10.3390/jof4040128.
The use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of as a model of immune response to different human pathogenic microorganisms.
在微生物学中，使用无脊椎动物进行体内研究在科学界已得到充分确立。[具体无脊椎动物名称]的幼虫是研究发病机制、新型抗菌化合物疗效和免疫反应的广泛使用的模型。[具体无脊椎动物名称]幼虫的免疫系统在结构和功能上与哺乳动物的先天免疫反应相似，这使得该模型适用于此类研究。在本综述中，讨论了细胞反应（血细胞活性：吞噬作用、结节形成和包囊形成）和体液反应（在血淋巴中释放的作为抗菌肽、黑化、凝血、自由基产生和初次免疫的反应或可溶性分子），强调了[具体无脊椎动物名称]作为对不同人类致病微生物免疫反应模型的用途。
