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硅胶乳房植入物的ABC:间变性大细胞淋巴瘤、生物膜与包膜挛缩

The A, B and C's of Silicone Breast Implants: Anaplastic Large Cell Lymphoma, Biofilm and Capsular Contracture.

作者信息

Mempin Maria, Hu Honghua, Chowdhury Durdana, Deva Anand, Vickery Karen

机构信息

Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, 2109, Australia.

出版信息

Materials (Basel). 2018 Nov 28;11(12):2393. doi: 10.3390/ma11122393.


DOI:10.3390/ma11122393
PMID:30486500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6316940/
Abstract

Breast implantation either for cosmetic or reconstructive e purposes is one of the most common procedures performed in plastic surgery. Biofilm infection is hypothesised to be involved in the development of both capsular contracture and anaplastic large cell lymphoma (ALCL). Capsular contracture is one of the principal reasons for breast revision surgery and is characterised by the tightening and hardening of the capsule surrounding the implant, and ALCL is an indolent lymphoma found only in women with textured implants. We describe the types of breast implants available with regard to their surface characteristics of surface area and roughness and how this might contribute to capsular contracture and/or biofilm formation. The pathogenesis of capsular contracture is thought to be due to biofilm formation on the implant, which results in on-going inflammation. We describe the current research into breast implant associated ALCL and how implant properties may affect its pathogenesis, with ALCL only occurring in women with textured implants.

摘要

乳房植入术无论是用于美容还是重建目的,都是整形外科中最常见的手术之一。生物膜感染被认为与包膜挛缩和间变性大细胞淋巴瘤(ALCL)的发生有关。包膜挛缩是乳房修复手术的主要原因之一,其特征是植入物周围的包膜收紧和硬化,而ALCL是一种仅在使用表面有纹理的植入物的女性中发现的惰性淋巴瘤。我们描述了现有乳房植入物的类型及其表面积和粗糙度等表面特征,以及这可能如何导致包膜挛缩和/或生物膜形成。包膜挛缩的发病机制被认为是由于植入物上形成生物膜,从而导致持续的炎症。我们描述了目前对乳房植入物相关ALCL的研究,以及植入物特性可能如何影响其发病机制,因为ALCL仅发生在使用表面有纹理的植入物的女性中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/5f626d0b8923/materials-11-02393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/6302366d16b1/materials-11-02393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/595a84fe3bd7/materials-11-02393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/5f626d0b8923/materials-11-02393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/6302366d16b1/materials-11-02393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/595a84fe3bd7/materials-11-02393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc5/6316940/5f626d0b8923/materials-11-02393-g003.jpg

相似文献

[1]
The A, B and C's of Silicone Breast Implants: Anaplastic Large Cell Lymphoma, Biofilm and Capsular Contracture.

Materials (Basel). 2018-11-28

[2]
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[3]
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[5]
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[6]
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[7]
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[9]
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[10]
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引用本文的文献

[1]
Breast Cancer Hormone Therapy Modulates Breast Implant Capsular Contracture.

Plast Reconstr Surg Glob Open. 2025-8-5

[2]
Comparative microbiome analysis of contracted breast capsules: a cross-sectional study.

BMC Microbiol. 2025-7-2

[3]
Harnessing the power of physicochemical material property screening to direct breast epithelial and breast cancer cells.

Bioact Mater. 2025-4-26

[4]
SMI-Capsular Fibrosis and Biofilm Dynamics: Molecular Mechanisms, Clinical Implications, and Antimicrobial Approaches.

Int J Mol Sci. 2024-10-30

[5]
Breast Implants: Low Rate of Annual Check-Ups Results in Delayed Presentation of Ruptured Implants.

J Clin Med. 2024-10-31

[6]
Importance of Adapting the Surgical Technique to the Characteristics of the Breast Implant Surface Type.

Aesthet Surg J. 2024-11-15

[7]
The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.

Proteomes. 2024-8-6

[8]
In Vivo Comparison of the Efficacy and Duration of Local Antibiotics on Smooth, Textured and Polyurethane Implant Surfaces.

Aesthetic Plast Surg. 2024-12

[9]
Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis.

Front Immunol. 2024

[10]
Surface Topography, Microbial Adhesion, and Immune Responses in Silicone Mammary Implant-Associated Capsular Fibrosis.

Int J Mol Sci. 2024-3-9

本文引用的文献

[1]
The Functional Influence of Breast Implant Outer Shell Morphology on Bacterial Attachment and Growth.

Plast Reconstr Surg. 2018-10

[2]
How to Diagnose and Treat Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Plast Reconstr Surg. 2018-4

[3]
Gastrointestinal lymphomas: French Intergroup clinical practice recommendations for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFH).

Dig Liver Dis. 2017-12-18

[4]
Preliminary 3-Year Evaluation of Experience With SilkSurface and VelvetSurface Motiva Silicone Breast Implants: A Single-Center Experience With 5813 Consecutive Breast Augmentation Cases.

Aesthet Surg J. 2018-5-15

[5]
Functional biocompatibility testing of silicone breast implants and a novel classification system based on surface roughness.

J Mech Behav Biomed Mater. 2017-6-27

[6]
Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand: High-Surface-Area Textured Implants Are Associated with Increased Risk.

Plast Reconstr Surg. 2017-10

[7]
U.S. Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Plast Reconstr Surg. 2017-5

[8]
Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Aesthet Surg J. 2016-7

[9]
Bacterial Biofilm Infection Detected in Breast Implant-Associated Anaplastic Large-Cell Lymphoma.

Plast Reconstr Surg. 2016-6

[10]
Capsular Contracture after Breast Augmentation: An Update for Clinical Practice.

Arch Plast Surg. 2015-9

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