CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, P. R. China.
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics (IHEP), Chinese Academy of Sciences, Beijing 100049, P. R. China.
J Nanosci Nanotechnol. 2019 Apr 1;19(4):1875-1888. doi: 10.1166/jnn.2019.16287.
Selenium is an important trace element. Many studies have proved that selenium can protect liver tissues by reducing response of immune inflammation and inducing high levels of ROS to promote tumor apoptosis. It can also participate in metabolism and involve in expression of selenoproteins. Selenoproteins also play a key role in liver diseases with regulating ROS and relating factors. In this review, we summarized the metabolic pathways of selenium intake and their bio-functions on liver diseases (Hepatoma, Cirrhosis and hepatitis). Moreover, the related molecular mechanisms are analyzed and discussed. Selenoproteins may be a promising target for liver diseases treatment.
硒是一种重要的微量元素。许多研究已经证明，硒可以通过减少免疫炎症反应和诱导高水平的 ROS 来促进肿瘤凋亡，从而保护肝组织。它还可以参与代谢，并涉及到硒蛋白的表达。硒蛋白在调节 ROS 和相关因素方面也在肝脏疾病中起着关键作用。在这篇综述中，我们总结了硒摄入的代谢途径及其对肝脏疾病（肝癌、肝硬化和肝炎）的生物功能。此外，还分析和讨论了相关的分子机制。硒蛋白可能是治疗肝脏疾病的一个有前途的靶点。
