Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Department of Intensive Care Unit, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Int Immunopharmacol. 2021 Jul;96:107790. doi: 10.1016/j.intimp.2021.107790. Epub 2021 May 24.
Selenium (Se) is an essential trace chemical element that is widely distributed worldwide. Se exerts its immunomodulatory and nutritional activities in the human body in the form of selenoproteins. Se has increasingly appeared as a potential trace element associated with many human diseases, including hepatocellular carcinoma (HCC). Recently, increasing evidence has suggested that Se and selenoproteins exert their immunomodulatory effects on HCC by regulating the molecules of oxidative stress, inflammation, immune response, cell proliferation and growth, angiogenesis, signaling pathways, apoptosis, and other processes in vitro cell studies and in vivo animal studies. Se concentrations are generally low in tissues of patients with HCC, such as blood, serum, scalp hair, and toenail. However, Se concentrations were higher in HCC patient tissues after Se supplementation than before supplementation. This review summarizes the significant relationship between Se and HCC, and details the role of Se as a novel immunomodulatory or immunotherapeutic approach against HCC.
硒（Se）是一种广泛分布于世界各地的必需微量元素。硒以硒蛋白的形式在人体内发挥其免疫调节和营养作用。硒作为一种潜在的微量元素，与许多人类疾病有关，包括肝细胞癌（HCC）。最近的证据表明，硒和硒蛋白通过调节氧化应激、炎症、免疫反应、细胞增殖和生长、血管生成、信号通路、细胞凋亡等分子，在体外细胞研究和体内动物研究中对 HCC 发挥免疫调节作用。在 HCC 患者的组织中，如血液、血清、头皮头发和趾甲，硒的浓度通常较低。然而，在硒补充后，HCC 患者组织中的硒浓度高于补充前。本综述总结了硒与 HCC 之间的显著关系，并详细阐述了硒作为一种新型免疫调节或免疫治疗 HCC 的方法的作用。
