真实世界数据库研究台湾地区股骨头缺血性坏死与糖尿病之间的关系。

Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan.

机构信息

College of Medicine, China Medical University, Taichung, Taiwan.

Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.

出版信息

Diabetes Care. 2019 Jan;42(1):39-43. doi: 10.2337/dc18-1258. Epub 2018 Nov 28.

DOI:10.2337/dc18-1258

PMID:30487230

Abstract

OBJECTIVE

No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan.

RESEARCH DESIGN AND METHODS

A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Program. There were 27,869 subjects aged 20-84 years with newly diagnosed diabetes from 2000 to 2012 as the group with diabetes. The group without diabetes included 111,476 sex- and age-matched subjects without diabetes. The incidence of avascular necrosis of the femoral head at the end of 2013 was measured. A multivariable Cox proportional hazards regression model was used to measure the hazard ratio (HR) and 95% CI for avascular necrosis of the femoral head associated with diabetes.

RESULTS

The overall incidence of avascular necrosis of the femoral head was 1.37-fold higher in the group with diabetes than in the group without diabetes (6.53 vs. 4.76 per 1,000 person-years [95% CI 1.31-1.43]). After adjusting for confounders, the HR of avascular necrosis of the femoral head was 1.16 (95% CI 1.11-1.21) for the subjects with diabetes compared with the subjects without diabetes.

CONCLUSIONS

Patients with diabetes have a 1.16-fold increased risk for developing avascular necrosis of the femoral head.

摘要

目的

目前尚无研究评估股骨头缺血性坏死与糖尿病之间的关系。本研究旨在评估台湾地区的这一问题。

研究设计和方法

本研究采用基于人群的队列研究，对台湾全民健康保险计划数据库进行了分析。共有 27869 例 20-84 岁新诊断为糖尿病的患者（2000 年至 2012 年）作为糖尿病组。无糖尿病组包括 111476 例年龄和性别相匹配的无糖尿病患者。于 2013 年底测量股骨头缺血性坏死的发生率。采用多变量 Cox 比例风险回归模型测量与糖尿病相关的股骨头缺血性坏死的风险比（HR）和 95%CI。