Division of Crop Foundation, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Wanju 55365, Korea.
Department of Biological Sciences, College of Natural Science, Chonbuk National University, Jeonju 54896, Korea.
Molecules. 2018 Nov 28;23(12):3119. doi: 10.3390/molecules23123119.
The number of patients with bone metabolic disorders including osteoporosis is increasing worldwide. These disorders often facilitate bone fractures, which seriously impact the patient's quality of life and could lead to further health complications. Bone homeostasis is tightly regulated to balance bone resorption and formation. However, many anti-osteoporotic agents are broadly categorized as either bone forming or anti-resorptive, and their therapeutic use is often limited due to unwanted side effects. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aims to clarify the bone protecting effects of oat bran water extract (OBWE) and its mode of action. OBWE inhibited RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclast differentiation by blocking c-Fos/NFATc1 through the alteration of I-κB. Furthermore, we found that OBWE enhanced BMP-2-stimulated osteoblast differentiation by the induction of Runx2 via Smad signaling molecules. In addition, the anti-osteoporotic activity of OBWE was also evaluated using an in vivo model. OBWE significantly restored ovariectomy-induced bone loss. These in vitro and in vivo results showed that OBWE has the potential to prevent and treat bone metabolic disorders including osteoporosis.
全球范围内，患有包括骨质疏松症在内的骨骼代谢紊乱的患者数量正在增加。这些疾病常导致骨折，严重影响患者的生活质量，并可能导致进一步的健康并发症。骨骼内环境平衡受严格调控，以维持骨吸收和形成的平衡。然而，许多抗骨质疏松药物广泛分为成骨或抗吸收药物，由于其不良副作用，其治疗用途往往受到限制。因此，需要安全有效的骨质疏松症治疗药物。本研究旨在阐明燕麦麸水提取物（OBWE）的护骨作用及其作用机制。OBWE 通过改变 I-κB 阻断 RANKL（核因子-κB 配体受体激活剂）诱导的破骨细胞分化，从而抑制 c-Fos/NFATc1。此外，我们发现 OBWE 通过 Smad 信号分子诱导 Runx2 增强 BMP-2 刺激的成骨细胞分化。此外，还通过体内模型评估了 OBWE 的抗骨质疏松活性。OBWE 显著恢复了卵巢切除引起的骨丢失。这些体外和体内结果表明，OBWE 具有预防和治疗包括骨质疏松症在内的骨骼代谢紊乱的潜力。
