富血小板血浆黏膜下注射在内镜下切除大型无蒂病变中的应用
Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions.
作者信息
Lorenzo-Zúñiga Vicente, de Vega Vicente Moreno, Bartolí Ramón, Marín Ingrid, Caballero Noemí, Bon Ignacio, Boix Jaume
机构信息
Department of Gastrointestinal Endoscopy, University Hospital Germans Trias/CIBERehd, Barcelona 08916, Spain.
出版信息
World J Gastrointest Endosc. 2018 Nov 16;10(11):348-353. doi: 10.4253/wjge.v10.i11.348.
AIM
To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions.
METHODS
Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered.
RESULTS
EMR was performed in 11 lesions (46.4 mm ± 4 mm, range 40-70 mm). Delayed bleeding or perforation was not observed in any patient. Mean ulcerated area at baseline was 22.7 cm ± 11.7 cm whereas at week 4 were 2.9 cm ± 1.5 cm. Patients treated with PRP showed a very high MHR after 4 wk (87.5%).
CONCLUSION
PRP is an easy-to-obtain solution with proven and favourable biological activities that could be used in advanced endoscopic resection.
目的
前瞻性评估黏膜下注射富血小板血浆（PRP）在内镜下切除大型无蒂病变中的疗效。
方法
11例患者接受了内镜下黏膜切除术（EMR），术前注射了在内镜检查时获取的PRP。对患者进行了1个月的随访。记录不良事件（延迟出血或穿孔）的发生率以及4周后黏膜愈合率（MHR）。
结果
对11个病变进行了EMR（46.4 mm±4 mm，范围40 - 70 mm）。未观察到任何患者出现延迟出血或穿孔。基线时平均溃疡面积为22.7 cm±11.7 cm，而在第4周时为2.9 cm±1.5 cm。接受PRP治疗的患者在4周后显示出非常高的MHR（87.5%）。
结论
PRP是一种易于获取的溶液，具有已证实的良好生物学活性，可用于高级内镜切除。
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