Endoscopy Unit, Hospital Universitari i Politècnic La Fe, Valencia.
Endoscopy Unit, Hospital Universitari Germans Trias i Pujol, Badalona.
Surg Laparosc Endosc Percutan Tech. 2021 Feb 3;31(3):376-377. doi: 10.1097/SLE.0000000000000898.
Platelet-rich plasma (PRP) has demonstrated efficacy as submucosal injection before endoscopic mucosal resection or local injection after endoscopic submucosal dissection of nonpedunculated colorectal lesions.
The EndoPRP study was a prospective single-center study to analyze the efficacy of PRP shield after endoscopic mucosal resection of large nonpedunculated colorectal lesio with impossible clip closure, assessed by the incidence of delayed bleeding (DB) and delayed perforation, and percentage of mucosal restoration after 4 weeks (mucosal healing rate).
Shielding technique with PRP was performed in 4 patients, aged 52 to 80, with 4 lesions at rectum (mean size 53.7±20.6 mm, range 35 to 80 mm). DB occurred in 1 lesion (25% of all lesions), no required blood transfusion or endoscopic treatment. No postoperative delayed perforation occurred. Mucosal healing rate was of 78.6% after 4 weeks.
PRP shield failed in prevent DB, probably due to migration and failure in the adherence in large wounds. Future comparative studies are needed to confirm these data.
富含血小板的血浆（PRP）已被证明在非息肉状结直肠病变的内镜黏膜切除术前行黏膜下注射或内镜黏膜下剥离术后局部注射有效。
EndoPRP 研究是一项前瞻性单中心研究，旨在分析 PRP 护罩在无法夹闭的大非息肉状结直肠病变内镜黏膜切除术后的疗效，通过延迟出血（DB）和延迟穿孔的发生率以及 4 周后黏膜恢复的百分比（黏膜愈合率）进行评估。
4 名年龄在 52 至 80 岁的患者接受了 PRP 护罩技术，共 4 个直肠病变（平均大小 53.7±20.6mm，范围 35 至 80mm）。1 个病变（所有病变的 25%）发生 DB，无需输血或内镜治疗。术后无延迟穿孔发生。4 周后黏膜愈合率为 78.6%。
PRP 护罩未能预防 DB，可能是由于在大伤口中迁移和附着失败。需要进一步的比较研究来证实这些数据。
