Miraghajani Maryam, Rafie Nahid, Hajianfar Hossein, Larijani Bagher, Azadbakht Leila
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK.
Int J Prev Med. 2018 Sep 17;9:84. doi: 10.4103/ijpvm.IJPVM_437_17. eCollection 2018.
Cancer is one of the leading causes of morbidity and mortality worldwide, which increases health-care costs. It has been reported that some dietary components such as aged garlic, one of the garlic preparations with no strong odor and harsh irritating taste, exhibits anticancer effects. This review summarizes the potential beneficial effects of aged garlic on cancer incidences as well as prevention and improvement of factors related to malignancy. Electronic databases, including MEDLINE, Web of Science, the Cochrane Library, and Google Scholar were searched. All study designs which were focused on cancer incidence, or indices related to malignancy as outcomes in human, animal, and human cells studies, and aged garlic and its ingredients as exposures were reviewed in accordance to the items for systematic reviews (PRISMA) guidelines. Initially, 304 articles were identified. Then, 25 articles which met the inclusion criteria were selected. Based on the evaluation, overall quality score of human studies was well. Although there were inconsistent evidence from human studies, results of the animal and laboratory results were mostly consistent. The overall findings may suggest that intakes of aged garlic are inversely associated with cancer. In this regard, the studies have shortcomings. Therefore, more precise investigations will be necessary to decide whether aged garlic consumption is recommendable as a part of cancer prevention or control programs. However, due to anticancer properties of aged garlic, its consumption along with healthy diet may have beneficial effects on cancer.
癌症是全球发病和死亡的主要原因之一，这增加了医疗保健成本。据报道，一些饮食成分，如陈化大蒜，这种大蒜制品没有强烈气味和刺鼻味道，具有抗癌作用。本综述总结了陈化大蒜对癌症发病率以及恶性肿瘤相关因素的预防和改善的潜在有益作用。检索了包括MEDLINE、科学网、考克兰图书馆和谷歌学术在内的电子数据库。根据系统评价（PRISMA）指南的项目，对所有以癌症发病率或与恶性肿瘤相关的指标为结局，以陈化大蒜及其成分作为暴露因素的人类、动物和人类细胞研究的研究设计进行了综述。最初，识别出304篇文章。然后，选择了25篇符合纳入标准的文章。基于评估，人类研究的总体质量得分良好。尽管人类研究的证据存在不一致，但动物和实验室研究结果大多一致。总体研究结果可能表明，食用陈化大蒜与癌症呈负相关。在这方面，这些研究存在不足之处。因此，需要更精确的调查来确定食用陈化大蒜是否作为癌症预防或控制计划的一部分是值得推荐的。然而，由于陈化大蒜具有抗癌特性，将其与健康饮食一起食用可能对癌症有有益影响。
