Departamento de Ecología, Center of Applied Ecology and Sustainability (CAPES), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins #340, 6513677, Santiago, Chile.
Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
J Comp Physiol B. 2019 Feb;189(1):143-152. doi: 10.1007/s00360-018-1195-9. Epub 2018 Nov 28.
The relationships between immunity, oxidative stress, and diet have not often been studied together. Despite this, it has been shown that dietary proteins can have effects on the functioning of the immune system and the oxidative status of animals. Here we evaluated the effects of dietary proteins on the response to an antigen and oxidative status of Octodon degus (Rodentia). We acclimated adult individuals to high-protein and low-protein diets and evaluated several aspects of the acute phase response and variables associated with oxidative status. After the immune challenge, animals acclimated to the high-protein diet had more inflammatory proteins and body mass losses than the group acclimated to a low-protein diet. Overall, the immune challenge increased the production of inflammatory proteins, total antioxidant capacity, lipid peroxidation, and duration of rest periods. In contrast, we did not find an interaction between diet and the challenge with the antigen. Overall, our results do not reveal an enhanced response to an antigen nor effects on the oxidative status of degus individuals subjected to a high-protein diet.
免疫、氧化应激和饮食之间的关系尚未经常一起进行研究。尽管如此，已经表明膳食蛋白质可以对动物的免疫系统功能和氧化状态产生影响。在这里，我们评估了膳食蛋白质对抗原反应和旱獭（啮齿动物）氧化状态的影响。我们使成年个体适应高蛋白和低蛋白饮食，并评估了急性期反应的几个方面以及与氧化状态相关的变量。在免疫挑战后，适应高蛋白饮食的动物比适应低蛋白饮食的动物具有更多的炎症蛋白和体重减轻。总体而言，免疫挑战增加了炎症蛋白、总抗氧化能力、脂质过氧化和休息时间的产生。相比之下，我们没有发现饮食与抗原挑战之间存在相互作用。总体而言，我们的结果并未显示出高蛋白饮食的个体对抗原的反应增强，也没有显示出对氧化状态的影响。
