Yaglova N V, Tsomartova D A, Yaglov V V
Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):422-424. doi: 10.1007/s10517-017-3819-6. Epub 2017 Aug 29.
We studied the effects of prenatal and postnatal exposure to low doses of DDT on secretion of basic catecholamines epinephrine and norepinephrine in pubertal and adult rats. It was found that the endocrine-disrupting chemical under study led to a progressive decrease in the content of epinephrine and especially norepinephrine in systemic circulation, which indicated their disturbed secretion by the adrenal medulla and sympathetic nervous system cells. In animals exposed to low doses of DDT in both pre- and postnatal periods, the decrease in catecholamine secretion after puberty was less pronounced than in animals exposed only during the postnatal period, which can indicate the development of compensatory processes.
我们研究了产前和产后暴露于低剂量滴滴涕（DDT）对青春期和成年大鼠体内基本儿茶酚胺（肾上腺素和去甲肾上腺素）分泌的影响。结果发现，所研究的内分泌干扰化学物质导致全身循环中肾上腺素尤其是去甲肾上腺素的含量逐渐降低，这表明肾上腺髓质和交感神经系统细胞对它们的分泌受到了干扰。在产前和产后均暴露于低剂量DDT的动物中，青春期后儿茶酚胺分泌的减少程度不如仅在产后暴露的动物明显，这可能表明出现了代偿过程。
