Kazakov O V, Kabakov A V, Poveshchenko A F, Raiter T V, Strunkin D N, Poveshchenko O V, Lykov A P, Konenkov V I
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2018 Dec;166(2):245-249. doi: 10.1007/s10517-018-4324-2. Epub 2018 Nov 28.
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. After resection of breast cancer followed by chemotherapy course, lymph transport activation, widening of the paracortex, enhanced proliferative activity of cells in the paracortex and B-cell zone, and reduced volumes of lymphoid nodules with and without germinal centers and medullary substance were revealed in comparison with rats subjected neoadjuvant chemotherapy.
对化学诱导乳腺癌的雌性Wistar大鼠进行了肠系膜淋巴结的形态计量分析。在未经治疗的乳腺癌对照大鼠中，窦系统的体积随着细胞介导免疫抑制、体液免疫抑制和巨噬细胞反应的形态学迹象的出现而平行增加。在化疗背景下，我们观察到副皮质和淋巴小结的体积减小，副皮质和B细胞区淋巴细胞增殖活性受到抑制，巨噬细胞含量减少。与接受新辅助化疗的大鼠相比，乳腺癌切除术后进行化疗疗程后，发现淋巴运输激活、副皮质增宽、副皮质和B细胞区细胞增殖活性增强，有生发中心和无生发中心的淋巴小结以及髓质物质的体积减小。
