Blagonravov M L, Medvedeva E V, Bryk A A, Goryachev V A, Rabinovich A E, Letoshneva A S, Demurov E A
V. A. Frolov Department of General Pathology and Pathological Physiology, Medical Institute, Peoples' Friendship University of Russia, Moscow, Russia.
Bull Exp Biol Med. 2018 Dec;166(2):192-196. doi: 10.1007/s10517-018-4312-6. Epub 2018 Nov 28.
We presented the results of our study of chronostructure of BP, HR, electrolyte excretion, and locomotor activity under conditions of "free-run rhythm" (light deprivation). In adult male Wistar-Kyoto (normotensive) and SHR (spontaneously hypertensive) rats, BP, biopotentials of the heart (ECG), and locomotor activity were recorded over 24 h by telemetric monitoring and the rate of excretion of electrolytes (Na, K, Ca, and Mg) during the nighttime and daytime hours was measured. It was found that under free-run rhythm, 24-h profiles of BP, HR, excretory function of the kidneys, and locomotor activity underwent more considerable changes in normotensive Wistar-Kyoto rats in comparison with hypertensive SHR rats. However, hypertensive rats demonstrated pronounced changes in rhythmic characteristics of HR, which can restrict adaptation reserves of the cardiovascular system.
我们展示了在“自由运行节律”（光照剥夺）条件下，对血压、心率、电解质排泄和运动活动的时间结构进行研究的结果。在成年雄性Wistar-Kyoto（正常血压）和SHR（自发性高血压）大鼠中，通过遥测监测记录24小时内的血压、心脏生物电位（心电图）和运动活动，并测量夜间和白天时段电解质（钠、钾、钙和镁）的排泄率。结果发现，在自由运行节律下，与高血压SHR大鼠相比，正常血压的Wistar-Kyoto大鼠的血压、心率、肾脏排泄功能和运动活动的24小时曲线变化更为显著。然而，高血压大鼠的心率节律特征出现了明显变化，这可能会限制心血管系统的适应储备。
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