Kohno I, Honma H, Nakamura T, Tamura K
Second Department of Internal Medicine, Yamanashi Medical College, Japan.
Chronobiologia. 1994 Jan-Jun;21(1-2):45-56.
Blood pressure, heart rate and physical activity in spontaneously hypertensive rats (SHR) were measured and compared with those of Wistar Kyoto rats (WKY) to see how these parameters vary with age and whether we can find a marker of essential hypertension among these variables. An automatic telemetric system was employed to measure these variables. In SHR, blood pressure and physical activity increased with age, but heart rate decreased. In WKY, neither blood pressure nor physical activity showed significant changes, but heart rate decreased with age. The 24h mean values of blood pressure, heart rate and physical activity were significantly higher in SHR than in WKY. The mean values of blood pressure, heart rate and physical activity were higher during nighttime than during daytime in both SHR and WKY. Circadian MESOR and amplitude of blood pressure increased simultaneously in SHR. These results are compatible with the concept that an increased amplitude of blood pressure may predict subsequent development of essential hypertension.
测量自发性高血压大鼠（SHR）的血压、心率和身体活动，并与Wistar Kyoto大鼠（WKY）进行比较，以观察这些参数如何随年龄变化，以及我们是否能在这些变量中找到原发性高血压的标志物。采用自动遥测系统测量这些变量。在SHR中，血压和身体活动随年龄增加，而心率下降。在WKY中，血压和身体活动均无显著变化，但心率随年龄下降。SHR的血压、心率和身体活动的24小时平均值显著高于WKY。在SHR和WKY中，夜间血压、心率和身体活动的平均值均高于白天。SHR中血压的昼夜中值和振幅同时增加。这些结果与血压振幅增加可能预示原发性高血压后续发展的概念相符。
