Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, UK.
Department of Surgery & Cancer, Imperial College London, London, UK.
Clin Endocrinol (Oxf). 2019 Mar;90(3):391-414. doi: 10.1111/cen.13906. Epub 2019 Jan 14.
The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomized, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women. Some studies suggest that testosterone therapy has additional effects, which include increased bone mineral density and decreased serum high-density lipoprotein (HDL) cholesterol. Furthermore, the long-term safety profile of testosterone therapy in postmenopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating postmenopausal women.
绝经后雌激素缺乏的临床后遗症是毫无疑问的。然而，睾酮在绝经期间的病理生理学作用尚不清楚。几项随机、安慰剂对照的临床试验表明，睾酮治疗可改善绝经后妇女的性功能。一些研究表明，睾酮治疗还有其他作用，包括增加骨密度和降低血清高密度脂蛋白（HDL）胆固醇。此外，睾酮治疗在绝经后妇女中的长期安全性尚不清楚。本文将对文献进行简明扼要的综述，以指导治疗绝经后妇女的临床医生。
