使用钯催化剂和碘化锌的组合将炔烃催化化学选择性和立体选择性半加氢制备E-烯烃
Catalytic Chemoselective and Stereoselective Semihydrogenation of Alkynes to E-Alkenes Using the Combination of Pd Catalyst and ZnI.
作者信息
Maazaoui Radhouan, Abderrahim Raoudha, Chemla Fabrice, Ferreira Franck, Perez-Luna Alejandro, Jackowski Olivier
机构信息
Sorbonne Université, CNRS , Institut Parisien de Chimie Moléculaire (IPCM) , F-75252 Paris Cedex 05 , France.
Université de Carthage, Faculté des Sciences de Bizerte , Laboratoire de Synthèse Hétérocyclique , 7021 Jarzouna , Bizerte , Tunisia.
出版信息
Org Lett. 2018 Dec 7;20(23):7544-7549. doi: 10.1021/acs.orglett.8b03295. Epub 2018 Nov 29.
An efficient E-selective semihydrogenation of internal alkynes was developed under low dihydrogen pressure and low reaction temperature from commercially available reagents: ClPd(PPh), Zn, and ZnI. Kinetic studies and control experiments underline the significant role of ZnI in this process under H atmosphere, establishing that the transformation involves syn-hydrogenation followed by isomerization. This simple and easy-to-handle system provides a route to E-alkenes under mild conditions.
在低氢气压力和低反应温度下，利用市售试剂ClPd(PPh)、Zn和ZnI，开发了一种高效的内炔烃E-选择性半氢化反应。动力学研究和对照实验强调了ZnI在H气氛下该过程中的重要作用，证实该转化过程包括顺式氢化然后异构化。这种简单且易于操作的体系为在温和条件下制备E-烯烃提供了一条途径。
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