Thomsen H S, Nielsen S L
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Denmark.
Dan Med Bull. 1988 Aug;35(4):393-5.
Cyclosporin A may decrease the perfusion of transplanted kidneys, especially if they are ischaemic. Therefore, monitoring of graft perfusion was performed with intravenous 99mTc pertechnetate angiography in 25 patients within 36 hours after renal transplantation and repeated 24 or 48 hours later and then again 48 hours later. In all patients, immunosuppression was performed with triple therapy (low dose prednisone, azathioprine, and cyclosporin A) which included a delay in cyclosporin A administration to the second postoperative day. Treatment with triple therapy did not cause a decrease in renal blood flow in the days immediately after transplantation as single therapy with high-dose cyclosporin A has been reported to do.
环孢素A可能会降低移植肾的灌注，尤其是在移植肾缺血的情况下。因此，对25例肾移植患者在术后36小时内进行了静脉注射高锝[99mTc]酸盐血管造影以监测移植肾灌注，并在24或48小时后以及再48小时后重复进行。所有患者均采用三联疗法（低剂量泼尼松、硫唑嘌呤和环孢素A）进行免疫抑制，其中环孢素A延迟至术后第二天给药。与据报道高剂量环孢素A单药治疗在移植后即刻会导致肾血流减少不同，三联疗法在移植后的几天内并未引起肾血流减少。
