Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine (Dr Shinawi); Cooperative Studies Program Coordinating Center, Edward Hines Jr. VA Hospital, Hines, Illinois (Ms Alpern, Ms Dannenfeldt, Dr Reda); Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts (Dr Toomey); and Washington University School of Medicine (Dr Blanchard), St. Louis, Missouri.
J Occup Environ Med. 2019 Apr;61(4):263-270. doi: 10.1097/JOM.0000000000001508.
The aim of the study was to examine the prevalence of birth defects among children born to Gulf War veterans.
Seven hundred eighty-eight singleton children born after the war to 522 veterans (262 Gulf War-deployed, DV; 260 non-deployed, NDV) underwent physical examinations focusing on major and minor birth defects and other findings.
We found no differences between children of DV and NDV in the prevalence of major birth defects or other findings. However, children of DV women were more likely to have minor birth defects compared with children of NDV women (DV 22% NDV 4.8%, odds ratio: 5.47, confidence interval: 2.06, 14.55), mainly due to increased incidence of minor eye and musculoskeletal birth defects.
Our data show that deployment of women to the Persian Gulf arena was associated with increased risk of minor birth defects in their offspring.
本研究旨在调查海湾战争退伍军人子女中出生缺陷的发生率。
对 522 名退伍军人（262 名海湾战争部署人员，DV；260 名非部署人员，NDV）的 788 名单胎儿童进行了体格检查，重点检查了主要和次要的出生缺陷及其他发现。
我们未发现 DV 组与 NDV 组儿童在主要出生缺陷或其他发现方面存在差异。然而，与 NDV 组相比，DV 组儿童出现轻微出生缺陷的可能性更高（DV 22%，NDV 4.8%，优势比：5.47，置信区间：2.06，14.55），主要是由于轻微眼部和肌肉骨骼出生缺陷的发生率增加。
我们的数据表明，女性部署到波斯湾地区与她们后代出现轻微出生缺陷的风险增加有关。
