Bukowinski Anna T, DeScisciolo Connie, Conlin Ava Marie S, K Ryan Margaret A, Sevick Carter J, Smith Tyler C
Deployment Health Research Department, Naval Health Research Center, San Diego, California 92106-3521, USA.
Birth Defects Res A Clin Mol Teratol. 2012 Sep;94(9):721-8. doi: 10.1002/bdra.23062. Epub 2012 Aug 18.
Concerns about reproductive health persist among U.S. military members who served in the 1990-1991 Gulf War. This study explores the long-term impact of 1990-1991 Gulf War deployment on the prevalence of birth defects among infants of Gulf War veterans.
Health care data from the Department of Defense Birth and Infant Health Registry and demographic and deployment information from the Defense Manpower Data Center were used to identify infants born between 1998 and 2004 to both male and female 1990-1991 Gulf War veterans. Multivariable logistic regression models estimated the adjusted odds of any birth defect and eight specific birth defects among infants of deployers versus non-deployers. In addition, birth defects were evaluated among infants born to 1990-1991 Gulf War veterans with deployment-specific exposures.
Among 178,766 infants identified for these analyses, 3.4% were diagnosed with a birth defect in the first year of life. Compared to infants of non-deployers, infants of deployers were not at increased odds of being diagnosed with a birth defect, or any of eight specific birth defects, in the first year of life. A slightly increased prevalence of birth defects was observed among infants born to men who deployed to the 1990-1991 Gulf War for 153 to 200 days compared to those who deployed for 1 to 92 days. No other deployment-specific exposures were associated with birth defects in these infants.
The 1990-1991 Gulf War deployers, including those with specific exposures of concern, were not found to be at increased risk for having infants with birth defects 7 to 14 years after deployment.
曾参加1990 - 1991年海湾战争的美国军人对生殖健康问题仍存担忧。本研究探讨1990 - 1991年海湾战争部署对海湾战争退伍军人子女出生缺陷患病率的长期影响。
利用国防部出生与婴儿健康登记处的医疗保健数据以及国防人力数据中心的人口统计和部署信息，确定1998年至2004年间出生的、父母均为1990 - 1991年海湾战争退伍军人的婴儿。多变量逻辑回归模型估计了部署人员与非部署人员的子女出现任何出生缺陷及八种特定出生缺陷的校正比值比。此外，还对有特定部署暴露情况的1990 - 1991年海湾战争退伍军人所生婴儿的出生缺陷进行了评估。
在为这些分析确定的178,766名婴儿中，3.4%在出生后第一年被诊断出患有出生缺陷。与非部署人员的子女相比，部署人员的子女在出生后第一年被诊断出患有出生缺陷或八种特定出生缺陷中的任何一种的几率并未增加。与部署1至92天的男性所生婴儿相比，部署到1990 - 1991年海湾战争153至200天的男性所生婴儿的出生缺陷患病率略有上升。在这些婴儿中，没有发现其他特定部署暴露与出生缺陷有关。
未发现1990 - 1991年海湾战争部署人员，包括那些有特定关注暴露情况的人员，在部署7至14年后生育有出生缺陷婴儿的风险增加。
