连续多天模拟野外灭火作业中急性补充谷氨酰胺对炎症和疲劳标志物的影响。
The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting.
机构信息
Department of Health, Exercise, and Sport Science, College of Education, Exercise Physiology Lab, Johnson Center B143 MSC04 2610, University of New Mexico, Albuquerque, New Mexico.
出版信息
J Occup Environ Med. 2019 Feb;61(2):e33-e42. doi: 10.1097/JOM.0000000000001507.
OBJECTIVE
To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.
METHODS
Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38 °C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4 hours post-exercise on both days.
RESULTS
Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.
CONCLUSIONS
Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.
目的
研究口服谷氨酰胺补充剂对模拟野外灭火（WLFF）任务中热条件下连续两天的炎症和疲劳的影响。
方法
11 名男性和女性在环境室（38°C，35%相对湿度）中模拟野外灭火前后分别摄入谷氨酰胺补充剂或安慰剂。在两天的运动前后测量主观疲劳、炎症标志物和细胞应激。
结果
与安慰剂相比，谷氨酰胺补充剂后胃肠道损伤、主观疲劳和感知用力评分较低。谷氨酰胺试验的两天 HSP70 和核因子 kappa-抑制剂 alpha（IκBα）水平均高于安慰剂。
结论
谷氨酰胺补充剂可能有助于提高 WLFF 中灭火后的恢复能力。这可能是由于 HSP70 的上调，抑制炎症并防止胃肠道（GI）屏障损伤。
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