Steel S A, Pearce J M, Chamberlain G
Fetal Welfare Laboratory, St. George's Hospital Medical School, London, U.K.
Eur J Obstet Gynecol Reprod Biol. 1988 Aug;28(4):279-87. doi: 10.1016/0028-2243(88)90014-7.
Two hundred primiparae underwent continuous-wave Doppler investigation of the uteroplacental circulation at 18-20 weeks gestation as a possible screening test for hypertension in pregnancy. Seventy-five women with abnormal waveforms suggestive of high uteroplacental resistance were tested again at 24 weeks when 21 demonstrated a persistent abnormality. Only nine (43%) of these went on to have an uncomplicated pregnancy, as compared with 150 (84%) of the remainder. Seventeen (8.5%) of the women in the study developed a hypertensive disorder of pregnancy, five of whom had abnormal waveforms at 18-20 weeks and at 24 weeks. These five women had a more severe degree of hypertension with proteinuria or intra-uterine growth retardation, and two required clinical intervention before term. The remaining 12 women were delivered at term of average, or heavier than average babies. Doppler investigation of the uteroplacental circulation at 24 weeks may prove to be a sensitive screening test for later severe pre-eclampsia with intra-uterine growth retardation.
200名初产妇在妊娠18 - 20周时接受了子宫胎盘循环的连续波多普勒检查，作为妊娠期高血压的一项可能的筛查试验。75名波形异常提示子宫胎盘阻力高的女性在24周时再次接受检查，其中21名仍表现为持续异常。这些女性中只有9名（43%）妊娠过程顺利，其余150名（84%）妊娠过程顺利。该研究中有17名（8.5%）女性发生了妊娠期高血压疾病，其中5名在18 - 20周和24周时波形均异常。这5名女性患有更严重程度的高血压并伴有蛋白尿或胎儿宫内生长受限，其中2名在足月前需要临床干预。其余12名女性足月分娩出平均体重或高于平均体重的婴儿。妊娠24周时子宫胎盘循环的多普勒检查可能被证明是对后期伴有胎儿宫内生长受限的重度子痫前期的一项敏感筛查试验。
