Rodgers V D, Kagnoff M F
University of California, San Diego.
Gastroenterol Clin North Am. 1988 Sep;17(3):487-94.
Significant abnormalities in the distribution of lymphocyte subsets have been noted in the intestinal mucosa of ARC and AIDS patients. Abnormalities are most striking among the CD4 helper-inducer T-cell subset and likely reflects the direct effects of HIV infection of those cells. A deficiency in CD4-positive T cells in the intestinal mucosa potentially could result in significant abnormalities in mucosal immune function, including defects both in cell-mediated immunity and in the secretory IgA system. Such alterations in mucosal immunity and mucosal defense may render AIDS and ARC subjects susceptible to enteric infections and systemic infections in which the intestinal tract is the portal of entry.
在艾滋病相关综合征（ARC）和艾滋病患者的肠道黏膜中，已发现淋巴细胞亚群分布存在显著异常。这些异常在CD4辅助诱导性T细胞亚群中最为明显，可能反映了HIV对这些细胞的直接感染作用。肠道黏膜中CD4阳性T细胞的缺乏可能会导致黏膜免疫功能出现显著异常，包括细胞介导免疫和分泌型IgA系统的缺陷。黏膜免疫和黏膜防御的这种改变可能使艾滋病和ARC患者易患肠道感染以及以肠道为入口的全身感染。
