Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland.
Atherosclerosis. 2019 Jan;280:92-98. doi: 10.1016/j.atherosclerosis.2018.11.007. Epub 2018 Nov 15.
In the 1960s and 1970s, Finland, mortality due to coronary heart disease (CHD) was over 30% higher among Finns residing in the east of the country compared with those residing in the west. Today, CHD mortality remains 20% higher among eastern Finns. The higher incidence of CHD mortality among eastern Finns has largely been explained by higher risk factor levels. Using a unique longitudinal cohort, we aimed to determine if participants who resided in eastern Finland during childhood had higher CHD risk factors in adulthood and from childhood to adulthood.
The study population included 2063 participants of the Cardiovascular Risk in Young Finns Study, born during the period 1962-1977, with risk factor data available from baseline (1980) when participants were aged 3-18 years, and had risk factor data collected again in adulthood (2011) when aged 34-49 years.
Adult CHD risk factor profile was similar for those who resided in eastern or western Finland in childhood. Over life-course from 1980 to 2011, those subjects with childhood residency in eastern Finland had, on average, higher systolic (p = 0.006) and diastolic (p = 0.0009) blood pressures, total (p = 0.01) and LDL-cholesterol (p = 0.01), triglycerides (p = 0.04), apoB (p = 0.02), and serum glucose (p < 0.0001) than those who resided in western Finland in childhood.
Our sample of adult Finns aged 34-49 years had a similar CHD risk factor profile irrespective of whether they resided in eastern or western Finland during their childhood. However, when considering participants risk factor profiles over a 31-year period, those who resided in eastern Finland in childhood were associated with a less favorable CHD risk factor profile than those who resided in western Finland in childhood. The observed differences suggest that future CHD mortality might remain higher in eastern Finland compared with western Finland.
20 世纪 60 年代和 70 年代，与居住在芬兰西部的人相比，居住在芬兰东部的人的冠心病（CHD）死亡率高出 30%以上。如今，东部芬兰人的 CHD 死亡率仍高出 20%。东部芬兰人 CHD 死亡率较高在很大程度上可以用更高的危险因素水平来解释。利用独特的纵向队列，我们旨在确定在童年时居住在芬兰东部的参与者在成年期以及从童年到成年期是否具有更高的 CHD 危险因素。
该研究人群包括心血管风险在年轻芬兰人中的 2063 名参与者，他们出生于 1962-1977 年期间，在基线（1980 年）时可获得参与者 3-18 岁时的危险因素数据，并且在成年时（2011 年）再次收集了危险因素数据，年龄为 34-49 岁。
在童年时期，居住在芬兰东部或西部的成年人的 CHD 危险因素特征相似。从 1980 年到 2011 年的整个生命过程中，那些在童年时期居住在芬兰东部的人平均血压（收缩压，p = 0.006；舒张压，p = 0.0009）、总胆固醇（p = 0.01）和 LDL 胆固醇（p = 0.01）、甘油三酯（p = 0.04）、载脂蛋白 B（p = 0.02）和血清葡萄糖（p < 0.0001）均高于童年时期居住在芬兰西部的人。
我们的样本中，34-49 岁的成年芬兰人无论在童年时期居住在芬兰东部还是西部，其 CHD 危险因素特征相似。然而，当考虑参与者在 31 年期间的危险因素特征时，那些在童年时期居住在芬兰东部的人比那些在童年时期居住在芬兰西部的人具有更不利的 CHD 危险因素特征。观察到的差异表明，与芬兰西部相比，未来芬兰东部的 CHD 死亡率可能仍然较高。
