Department of Dermatology, Brigham and Women's Hospital, 41 Avenue Louis Pasteur, Room 319, Boston, MA 02115, USA; Melanoma Program, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.
Department of Dermatology, Brigham and Women's Hospital, 41 Avenue Louis Pasteur, Room 319, Boston, MA 02115, USA; Melanoma Program, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.
Hematol Oncol Clin North Am. 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005.
Melanoma is an increasingly common cancer in the United States, although mortality has likely stabilized. Diagnosis relies on a skilled practitioner with the aid of dermoscopy and initial local surgical management is a mainstay of treatment. Recent changes in staging emphasize continued use of sentinel lymph node biopsy to aid in prognostication although routine complete lymph node dissection has fallen out of favor. Advances in systemic treatment options, including targeted and immunotherapy, have dramatically changed the treatment paradigm for advanced melanoma and improved outcome. Prevention via sun protection remains a critical tool in efforts to limit the burden of this disease.
黑色素瘤在美国是一种日益常见的癌症,尽管死亡率可能已经稳定下来。诊断依赖于具有皮肤镜辅助技能的医生,而初始的局部手术治疗是治疗的主要方法。最近的分期变化强调继续使用前哨淋巴结活检来帮助预测预后,尽管常规的完全淋巴结清扫已经不再流行。在系统治疗选择方面的进展,包括靶向治疗和免疫治疗,已经极大地改变了晚期黑色素瘤的治疗模式,并改善了预后。通过防晒来预防仍然是限制这种疾病负担的重要工具。