与系统评价和荟萃分析方案相关的不良妊娠和新生儿结局。
Adverse pregnancy and neonatal outcomes associated with a systematic review and meta-analysis protocol.
机构信息
Public Health Interventions Research Group, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
出版信息
BMJ Open. 2018 Nov 28;8(11):e024175. doi: 10.1136/bmjopen-2018-024175.
INTRODUCTION
Several bacterial sexually transmitted and genital mycoplasma infections during pregnancy have been associated with poor pregnancy and perinatal outcomes. Comprehensive and systematic information about associations between sexually transmitted infections (STI) and genital infections in pregnancy and adverse perinatal outcomes is needed to improve understanding about the evidence for causal associations between these infections and adverse pregnancy and neonatal outcomes. Our primary objective is to systematically review the literature about associations between: (1) in pregnancy and preterm birth; (2) in pregnancy and preterm birth; (3) and/or in pregnancy and preterm birth.
METHODS AND ANALYSIS
We will undertake a systematic search of Medline, Excerpta Medica database and the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature. Following an initial screening of titles by one reviewer, abstracts will be independently assessed by two reviewers before screening of full-text articles. To exclude a manuscript, both reviewers need to agree on the decision. Any discrepancies will be resolved by discussion, or the adjudication of a third reviewer. Studies will be included if they report testing for one or more of during pregnancy and report pregnancy and/or birth outcomes. In this review, the primary outcome is preterm birth. Secondary outcomes are premature rupture of membranes, low birth weight, spontaneous abortion, stillbirth, neonatal mortality and ophthalmia neonatorum. We will use standard definitions, or definitions reported by study authors. We will examine associations between exposure and outcome in forest plots, using the I statistic to examine between study heterogeneity. Where appropriate, we will use meta-analysis to combine results of individual studies.
ETHICS AND DISSEMINATION
This systematic review of published literature does not require ethical committee approval. Results of this review will be published in a peer reviewed, open access journal.
PROSPERO REGISTRATION NUMBER
CRD42016050962.
简介
怀孕期间几种细菌性性传播和生殖器支原体感染与不良妊娠和围产儿结局有关。为了更好地了解这些感染与不良妊娠和新生儿结局之间因果关系的证据，需要综合和系统地了解妊娠期间性传播感染（STI）和生殖器感染与不良围产儿结局之间的关联。我们的主要目的是系统地综述文献中以下方面的关联：（1） 与早产的关系；（2） 与早产的关系；（3） 与早产的关系。
方法和分析
我们将对 Medline、Excerpta Medica 数据库和 Cochrane 图书馆以及 Cumulative Index to Nursing and Allied Health Literature 进行系统检索。在由一名评审员进行初步标题筛选后，两名评审员将独立评估摘要，然后再筛选全文文章。为了排除一篇手稿，两名评审员都需要对该决定达成一致。如果存在分歧，则通过讨论或第三名评审员的裁决来解决。如果研究报告了在妊娠期间检测一种或多种 ，并报告了妊娠和/或分娩结局，则将纳入研究。在本综述中，主要结局是早产。次要结局是胎膜早破、低出生体重、自然流产、死产、新生儿死亡率和新生儿眼炎。我们将使用标准定义或研究作者报告的定义来检查暴露与结局之间的关联。我们将使用森林图检查研究间异质性，使用 I 统计量检查研究间异质性。在适当的情况下，我们将使用荟萃分析来合并个别研究的结果。
伦理和传播
本系统综述对已发表文献的评价不需要伦理委员会的批准。本综述的结果将发表在同行评议的开放获取期刊上。
PROSPERO 注册号：CRD42016050962。
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