胃肠道间质瘤的手术切缘是否不同？
Is the Surgical Margin in Gastrointestinal Stromal Tumors Different?
作者信息
Rutkowski Piotr, Skoczylas Jacek, Wisniewski Piotr
机构信息
Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.
Department of Pathology, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.
出版信息
Visc Med. 2018 Oct;34(5):347-352. doi: 10.1159/000491649. Epub 2018 Aug 24.
Abstract
BACKGROUND
Radical surgical excision is the mainstay of therapy of primary, nonmetastatic gastrointestinal stromal tumors (GIST) and margin status after surgery is a significant prognostic factor.
METHODS AND RESULTS
The aim of this paper is to review principles in primary GIST surgery, i.e. differences between R0, R1, and R2 resection, to describe how surgical margin status and tumor intraperitoneal rupture influence the patients' outcome, and how this may be effected by neoadjuvant and adjuvant treatment in locally advanced tumors. A systematic search of literature published between 2000 and 2018 was performed regarding this topic.
CONCLUSION
Correct interpretation of margin status after surgery can be affected by many factors during operation and preparation of tissue.
摘要
背景
根治性手术切除是原发性、非转移性胃肠道间质瘤（GIST）治疗的主要手段，术后切缘状态是一个重要的预后因素。
方法与结果
本文旨在回顾原发性GIST手术的原则，即R0、R1和R2切除的差异，描述手术切缘状态和肿瘤腹腔内破裂如何影响患者的预后，以及局部晚期肿瘤的新辅助和辅助治疗如何对此产生影响。针对该主题对2000年至2018年发表的文献进行了系统检索。
结论
手术中及组织制备过程中的许多因素可能会影响对术后切缘状态的正确解读。
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