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Laparoscopic surgery versus open resection in patients with gastrointestinal stromal tumors: An updated systematic review and meta-analysis.胃肠道间质瘤患者的腹腔镜手术与开放切除术：一项更新的系统评价和荟萃分析。
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Comparison of the post-operative outcomes and survival of laparoscopic versus open resections for gastric gastrointestinal stromal tumors: A multi-center prospective cohort study.腹腔镜与开腹胃胃肠间质瘤切除术的术后结局和生存比较：多中心前瞻性队列研究。
Int J Surg. 2016 Sep;33 Pt A:65-71. doi: 10.1016/j.ijsu.2016.07.064. Epub 2016 Jul 28.
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Indications for surgery in advanced/metastatic GIST.晚期/转移性 GIST 的手术适应证。
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Interpretation of Pathologic Margin after Endoscopic Resection of Gastrointestinal Stromal Tumor.胃肠道间质瘤内镜切除术后病理切缘的解读
Clin Endosc. 2016 May;49(3):229-31. doi: 10.5946/ce.2016.035. Epub 2016 Apr 7.
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Definition and clinical significance of tumour rupture in gastrointestinal stromal tumours of the small intestine.定义和临床意义的肿瘤破裂的胃肠道间质肿瘤的小肠。
Br J Surg. 2016 May;103(6):684-691. doi: 10.1002/bjs.10104. Epub 2016 Mar 14.
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Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis.原发性胃肠道间质瘤镜下切缘阳性的预后作用：一项系统评价和Meta分析
Sci Rep. 2016 Feb 19;6:21541. doi: 10.1038/srep21541.

胃肠道间质瘤的手术切缘是否不同？

Is the Surgical Margin in Gastrointestinal Stromal Tumors Different?

作者信息

Rutkowski Piotr, Skoczylas Jacek, Wisniewski Piotr

机构信息

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.

Department of Pathology, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.

出版信息

Visc Med. 2018 Oct;34(5):347-352. doi: 10.1159/000491649. Epub 2018 Aug 24.

DOI:10.1159/000491649
PMID:30498701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257087/
Abstract

BACKGROUND

Radical surgical excision is the mainstay of therapy of primary, nonmetastatic gastrointestinal stromal tumors (GIST) and margin status after surgery is a significant prognostic factor.

METHODS AND RESULTS

The aim of this paper is to review principles in primary GIST surgery, i.e. differences between R0, R1, and R2 resection, to describe how surgical margin status and tumor intraperitoneal rupture influence the patients' outcome, and how this may be effected by neoadjuvant and adjuvant treatment in locally advanced tumors. A systematic search of literature published between 2000 and 2018 was performed regarding this topic.

CONCLUSION

Correct interpretation of margin status after surgery can be affected by many factors during operation and preparation of tissue.

摘要

背景

根治性手术切除是原发性、非转移性胃肠道间质瘤（GIST）治疗的主要手段，术后切缘状态是一个重要的预后因素。

方法与结果

本文旨在回顾原发性GIST手术的原则，即R0、R1和R2切除的差异，描述手术切缘状态和肿瘤腹腔内破裂如何影响患者的预后，以及局部晚期肿瘤的新辅助和辅助治疗如何对此产生影响。针对该主题对2000年至2018年发表的文献进行了系统检索。

结论

手术中及组织制备过程中的许多因素可能会影响对术后切缘状态的正确解读。