Vaamonde-Martín Ricardo J, Ballesta-Ruiz Mónica, Sánchez-Gil Antonia, Fernández Juan Ángel, Martínez-Barba Enrique, Martínez-García Jerónimo, Gatta Gemma, Chirlaque-López María D
Service of Epidemiology, Region of Murcia Health Council, Ronda de Levante 11, 30008 Murcia, Spain.
Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 30120 Murcia, Spain.
Cancers (Basel). 2023 May 30;15(11):2994. doi: 10.3390/cancers15112994.
Gastro-Intestinal Stromal Tumours (GISTs) are a kind of neoplasm whose diagnosis in common clinical practice just started in the current century, implying difficulties for proper registration. Staff from the Cancer Registry of Murcia, in southeastern Spain, were commissioned by the EU Joint Action on Rare Cancers into a pilot study addressing GIST registration that also yielded a population-based depiction of GISTs in the region, including survival figures. We examined reports from 2001 to 2015 from hospitals as well as cases already present in the registry. The variables collected were sex, date of diagnosis, age, vital status, primary location, presence of metastases, and risk level according to Joensuu's Classification. In total, 171 cases were found, 54.4% occurred in males, and the mean age value was 65.0 years. The most affected organ was the stomach, with 52.6% of cases. Risk level was determined as "High" for 45.0%, with an increment of lower levels in recent years. Incidence for the year 2015 doubled that of 2001. Overall, the 5-year net survival estimation was 77.0%. The rising incidence magnitude is consistent with trends in other European countries. Survival evolution lacked statistical significance. A more interventional approach in clinical management could explain the increase in the proportion of "Low Risk GISTs" and the first occurrence of "Very Low Risk" in recent years.
胃肠道间质瘤（GISTs）是一种肿瘤，其在普通临床实践中的诊断于本世纪才刚刚开始，这意味着进行准确登记存在困难。西班牙东南部穆尔西亚癌症登记处的工作人员受欧盟罕见癌症联合行动委托，开展了一项关于GIST登记的试点研究，该研究还对该地区的GISTs进行了基于人群的描述，包括生存数据。我们查阅了2001年至2015年医院的报告以及登记处已有的病例。收集的变量包括性别、诊断日期、年龄、生命状态、原发部位、转移情况以及根据约恩苏分类法确定的风险水平。总共发现了171例病例，其中54.4%发生在男性身上，平均年龄值为65.0岁。受影响最严重的器官是胃，占病例的52.6%。45.0%的病例风险水平被确定为“高”，近年来较低风险水平的病例有所增加。2015年的发病率是2001年的两倍。总体而言，5年净生存估计为77.0%。发病率上升幅度与其他欧洲国家的趋势一致。生存演变缺乏统计学意义。临床管理中更具干预性的方法可能解释了近年来“低风险GISTs”比例的增加以及“极低风险”的首次出现。
