Department for Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasya, Isehara, Kanagawa, 259-1143, Japan.
Int Orthop. 2019 Apr;43(4):1011-1025. doi: 10.1007/s00264-018-4223-1. Epub 2018 Nov 29.
Low back pain is the primary cause of disability and is highly associated with progression of intervertebral disc degeneration. Current treatment options are limited and fail to address the origin of the problem. New advancements in cellular therapies might offer novel and potent strategies for low back pain patients. In this review, we summarize and discuss the contemporary status of in-human trials investigating cellular transplantation for treatment of low back pain. We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization.
下背痛是导致残疾的主要原因，与椎间盘退行性病变的进展高度相关。目前的治疗选择有限，无法解决问题的根源。细胞疗法的新进展可能为腰痛患者提供新的、有效的治疗策略。在这篇综述中，我们总结和讨论了目前正在进行的关于细胞移植治疗腰痛的人体临床试验的现状。我们旨在强调当前临床试验和后续商业化的趋势、缺点和障碍。
