Department of Orthopedics, University Hospital Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.
Department of Orthopedics, University Hospital Essen, Essen, Germany.
Eur J Appl Physiol. 2019 Feb;119(2):455-464. doi: 10.1007/s00421-018-4043-4. Epub 2018 Nov 29.
The tensiomyography (TMG) technique is increasingly used to determine muscle contractile properties in exercise and injury management. The present study investigated the informative value of TMG parameters in correlation with commonly used (creatine kinase, CK; myoglobin, Mb) and novel candidate biomarkers of muscle damage (heart-type fatty acid-binding protein, h-FABP; high-mobility group box 1, HMGB1).
Ten untrained men performed 6 × 10 eccentric contractions of the elbow flexors at 110% of the concentric one repetition maximum. CK, Mb, h-FABP, HMGB1, arm circumference, pain and TMG data, including maximal displacement (D) and temporal outcomes as the contraction time (T), sustained time (T), delay time (T), and relaxation time (T), were assessed pre-exercise, post-exercise, 20 min, 2 h and on the consecutive 3 days post-exercise.
CK and h-FABP significantly increased beginning at 24 h, Mb already increased at 2 h (p < 0.05). HMGB1 was only increased immediately post-exercise (p = 0.02). T and T remained unchanged, whereas T and T were significantly slower beginning at 24 h (p < 0.05). D was decreased within the first 24 h and after 72 h (p < 0.01). The % change from pre-exercise correlated for D with CK, Mb, and h-FABP the highest at 48 h (r = - 0.95, - 0.87 and - 0.79; p < 0.01) and for h-FABP with CK and Mb the highest at 24 h (r = 0.96 and 0.94, for all p < 0.001).
This study supports the correlation of TMG parameters with muscle damage markers after eccentric exercise. Therefore, TMG could represent a non-invasive and cost effective alternative to quantify the degree of muscle damage after exercise interventions.
张力肌描记术（TMG）技术越来越多地用于确定运动和损伤管理中的肌肉收缩特性。本研究调查了 TMG 参数与常用（肌酸激酶，CK；肌红蛋白，Mb）和新型候选肌肉损伤生物标志物（心脏型脂肪酸结合蛋白，h-FABP；高迁移率族蛋白 1，HMGB1）的相关性的信息价值。
10 名未经训练的男性以 110%的最大等长重复次数进行 6 次×10 次的肘屈肌离心收缩。在运动前、运动后、20 分钟、2 小时和运动后连续 3 天，评估 CK、Mb、h-FABP、HMGB1、臂围、疼痛和 TMG 数据，包括最大位移（D）和收缩时间（T）、持续时间（T）、延迟时间（T）和松弛时间（T）等时间参数。
CK 和 h-FABP 从 24 小时开始显著增加，Mb 从 2 小时开始增加（p < 0.05）。HMGB1 仅在运动后即刻增加（p = 0.02）。T 和 T 保持不变，而 T 和 T 从 24 小时开始明显变慢（p < 0.05）。D 在最初 24 小时内和 72 小时后减少（p < 0.01）。与 CK、Mb 和 h-FABP 相比，D 的预运动百分比变化在 48 小时时相关性最高（r = -0.95、-0.87 和-0.79；p < 0.01），与 h-FABP 的相关性在 24 小时时最高（r = 0.96 和 0.94，所有 p < 0.001）。
本研究支持 TMG 参数与离心运动后肌肉损伤标志物的相关性。因此，TMG 可以作为一种非侵入性且具有成本效益的替代方法来量化运动干预后的肌肉损伤程度。
