Prato F S, Wisenberg G, Marshall T P, Uksik P, Zabel P
Dept. of Nuclear Medicine, St. Joseph's Health Centre, London, Ontario, Canada.
J Nucl Med. 1988 Oct;29(10):1683-7.
Twenty-three mature Sprague-Dawley male and female rats were simultaneously injected with trace quantities of [153Gd]DTPA and [99mTc]DTPA and 0.5 mmol/kg of nonradioactive gadolinium DTPA. Rats were killed at 1 min, 5 min, 10 min, 15 min, and 30 min after the intracardiac bolus injection. The heart, lungs, liver, brain, kidney, and blood were excised and counted in a well-counter to determine the amount of the injected material in each organ and blood. In order for the percent of total injected activity to be determined, a technique was developed which allowed discrimination of the 140 keV gamma-ray of 99mTc from sum peaks of 153Gd when the latter is counted in a well-counter with 4 pi geometry. Although the distribution of the two DTPA compounds was qualitatively similar, statistical analysis indicated that the amount of 99mTc deposited in the lungs was higher than 153Gd (p = 0.03), the amount of 99mTc deposited in the kidneys was lower than 153Gd (p = 0.0004) and the amount of 99mTc in the blood was higher than 153Gd (p = 0.0022). This may be due to the greater binding of [99mTc]DTPA or its minor impurities to plasma proteins.
将23只成年斯普拉格-道利雌雄大鼠同时注射微量的[153钆]二乙三胺五乙酸（DTPA）和[99m锝]DTPA以及0.5毫摩尔/千克的非放射性钆DTPA。在心脏内推注注射后1分钟、5分钟、10分钟、15分钟和30分钟处死大鼠。取出心脏、肺、肝、脑、肾和血液，在井型计数器中计数，以确定每个器官和血液中注入物质的量。为了确定注入总活度的百分比，开发了一种技术，当153钆在具有4π几何形状的井型计数器中计数时，该技术能够将99m锝的140千电子伏特γ射线与153钆的和峰区分开来。尽管两种DTPA化合物的分布在质量上相似，但统计分析表明，沉积在肺中的99m锝量高于153钆（p = 0.03），沉积在肾中的99m锝量低于153钆（p = 0.0004），血液中的99m锝量高于153钆（p = 0.0022）。这可能是由于[99m锝]DTPA或其微量杂质与血浆蛋白的结合更强。
