Department of Pediatrics, University of Alabama at Birmingham.
Children's of Alabama.
J Pediatr Gastroenterol Nutr. 2019 Mar;68(3):301-305. doi: 10.1097/MPG.0000000000002212.
Youth with inflammatory bowel disease (IBD) demonstrate deficits in lean mass (LM) placing them at increased risk for future health problems, including reduction of bone mass and impaired bone architecture. Research suggests that deficits in LM are multifactorial, including influences from the disease and its treatment, and health behaviors such as diet and physical activity. Based on a systematic literature review examining factors related to LM deficits in IBD, this article presents a conceptual model to explain the development of LM in youth with IBD. The model considers predictors of LM across 4 domains: demographic; medical; diet; and physical activity. Much existing research is cross-sectional, but suggests multiple factors work together to promote or inhibit LM accrual in youth with IBD. The conceptual model, developed based on empirical findings to date, can be used to understand and further elucidate the process through which LM is developed and maintained, to inform the development of empirically supported clinical interventions, and to guide future research objectives and priorities.
炎症性肠病 (IBD) 患者的瘦体重 (LM) 存在不足，这使他们面临未来健康问题的风险增加，包括骨量减少和骨结构受损。研究表明，LM 的不足是多因素的，包括疾病及其治疗的影响，以及饮食和体育活动等健康行为。基于一项系统的文献综述，该综述检查了与 IBD 中 LM 不足相关的因素，本文提出了一个概念模型来解释 IBD 青少年 LM 的发展。该模型考虑了 4 个领域的 LM 预测因素：人口统计学；医学；饮食；和体育活动。虽然许多现有研究是横断面的，但它们表明多种因素共同作用，促进或抑制 IBD 青少年 LM 的积累。基于迄今为止的实证研究结果，该概念模型可用于理解和进一步阐明 LM 发展和维持的过程，为制定经验支持的临床干预措施提供信息，并指导未来的研究目标和重点。
