J Drugs Dermatol. 2021 Apr 1;20(4):461-465. doi: 10.36849/JDD.2021.5856.
Skin rejuvenation can be achieved with minimally invasive treatments using energy-based devices that feature reduced side effects and downtime. Post-treatment care is key to minimize any potential side effects and skin reactions such as erythema, dryness, or dyschromia.
The objective of this study was to evaluate the efficacy and patient satisfaction of a novel carboxytherapy gel mask compared with petroleum-based lanolin-containing ointment to accelerate wound healing facial post-nanofractional radiofrequency treatment.
Ten subjects were enrolled in this pilot, prospective, randomized, single-blind study and randomized into two arms. One arm received one nanofractional radiofrequency treatment with ointment right after and four consecutive days of ointment applications twice a day, while the second arm followed this regimen with a carboxytherapy gel mask application right after and four consecutive days after treatment. Investigator, safety, and patient assessments were conducted at 24 hours and one-week post treatment. Safety was monitored throughout. The primary endpoint was defined as the degree of investigator global assessment (IGA) in photodamage, pigmentation, and wrinkles using standardized photographs. Secondary endpoints included investigator-rated degree of erythema, edema, crusting, exudation, percentage healing, improvement of skin quality, and patient satisfaction.
Nine patients completed the study. There was improvement of one degree in IGA for photodamage, pigmentation and wrinkles in all patients using the carboxytherapy gel mask at the one-week follow up. Blinded investigator ratings showed significant improvement of dryness, erythema, edema, crusting, and percentage healing at the 24-hour follow up, with all patients remaining the same a week post treatment. All patients in the carboxytherapy group were satisfied with the treatment and had no adverse effects. Three patients in the petroleum-based lanolin-containing group experienced mild edema and acne breakout that resolved two weeks after treatment.
Carboxytherapy delivered via a gel mask after skin rejuvenation procedures is a safe and effective strategy to improve clinical outcomes and reduce post-treatment side effects. J Drugs Dermatol. 20(4):461-465. doi:10.36849/JDD.5856.
皮肤年轻化可以通过使用能量设备进行微创治疗来实现，这些设备具有减少副作用和停机时间的特点。治疗后的护理是关键，可以最大限度地减少任何潜在的副作用和皮肤反应，如红斑、干燥或色素沉着不均。
本研究的目的是评估一种新型的羧基疗法凝胶面膜与含石油基羊毛脂的软膏相比，加速面部纳米微针射频治疗后伤口愈合的疗效和患者满意度。
本研究采用前瞻性、随机、单盲试验设计，共纳入 10 名受试者，将其随机分为两组。一组在接受一次纳米微针射频治疗后立即使用软膏，并连续 4 天每天两次涂抹软膏；另一组在接受治疗后立即使用羧基疗法凝胶面膜，并在治疗后连续 4 天每天两次使用面膜。在治疗后 24 小时和 1 周时进行研究者、安全性和患者评估。整个过程中监测安全性。主要终点是使用标准化照片评估治疗后 24 小时和 1 周时研究者的整体评估（IGA）在光损伤、色素沉着和皱纹方面的程度。次要终点包括研究者评估的红斑、水肿、结痂、渗出、愈合百分比、皮肤质量改善和患者满意度。
9 名患者完成了研究。所有患者在治疗后 1 周时使用羧基疗法凝胶面膜，IGA 评分在光损伤、色素沉着和皱纹方面均有 1 度改善。盲法研究者评分显示，在治疗后 24 小时，干燥、红斑、水肿、结痂和愈合百分比显著改善，所有患者在治疗后 1 周时保持相同。所有使用羧基疗法的患者对治疗均满意，无不良反应。含石油基羊毛脂的软膏组中有 3 名患者出现轻度水肿和痤疮爆发，两周后消退。
在皮肤年轻化治疗后，通过凝胶面膜进行羧基疗法是一种安全有效的策略，可以改善临床效果，减少治疗后的副作用。
