Emerg Infect Dis. 2019 Feb;25(2):249-255. doi: 10.3201/eid2502.181011. Epub 2019 Feb 17.
Ebola virus (EBOV) can persist in immunologically protected body sites in survivors of Ebola virus disease, creating the potential to initiate new chains of transmission. From the outbreak in West Africa during 2014-2016, we identified 13 possible events of viral persistence-derived transmission of EBOV (VPDTe) and applied predefined criteria to classify transmission events based on the strength of evidence for VPDTe and source and route of transmission. For 8 events, a recipient case was identified; possible source cases were identified for 5 of these 8. For 5 events, a recipient case or chain of transmission could not be confidently determined. Five events met our criteria for sexual transmission (male-to-female). One VPDTe event led to at least 4 generations of cases; transmission was limited after the other events. VPDTe has increased the importance of Ebola survivor services and sustained surveillance and response capacity in regions with previously widespread transmission.
埃博拉病毒（EBOV）可在埃博拉病毒病幸存者的免疫保护部位持续存在，从而有潜力引发新的传播链。从 2014 年至 2016 年在西非暴发的疫情中，我们发现了 13 起可能由病毒持续存在引起的埃博拉病毒传播（VPDTe）事件，并应用预定义标准，根据 VPDTe 以及传播源和传播途径的证据强度，对传播事件进行分类。在 8 起事件中，发现了受感染病例；在这 8 起事件中，有 5 起可能确定了源病例。在 5 起事件中，无法确定受感染病例或传播链。5 起事件符合我们关于性传播（男传女）的标准。一起 VPDTe 事件至少导致了 4 代病例；其他事件发生后，传播受到限制。VPDTe 增加了埃博拉幸存者服务以及在以前广泛传播地区的持续监测和应对能力的重要性。
