埃博拉病毒感染与幸存者传播有关。
Ebola Virus Infection Associated with Transmission from Survivors.
出版信息
Emerg Infect Dis. 2019 Feb;25(2):249-255. doi: 10.3201/eid2502.181011. Epub 2019 Feb 17.
Abstract
Ebola virus (EBOV) can persist in immunologically protected body sites in survivors of Ebola virus disease, creating the potential to initiate new chains of transmission. From the outbreak in West Africa during 2014-2016, we identified 13 possible events of viral persistence-derived transmission of EBOV (VPDTe) and applied predefined criteria to classify transmission events based on the strength of evidence for VPDTe and source and route of transmission. For 8 events, a recipient case was identified; possible source cases were identified for 5 of these 8. For 5 events, a recipient case or chain of transmission could not be confidently determined. Five events met our criteria for sexual transmission (male-to-female). One VPDTe event led to at least 4 generations of cases; transmission was limited after the other events. VPDTe has increased the importance of Ebola survivor services and sustained surveillance and response capacity in regions with previously widespread transmission.
摘要
埃博拉病毒（EBOV）可在埃博拉病毒病幸存者的免疫保护部位持续存在，从而有潜力引发新的传播链。从 2014 年至 2016 年在西非暴发的疫情中，我们发现了 13 起可能由病毒持续存在引起的埃博拉病毒传播（VPDTe）事件，并应用预定义标准，根据 VPDTe 以及传播源和传播途径的证据强度，对传播事件进行分类。在 8 起事件中，发现了受感染病例；在这 8 起事件中，有 5 起可能确定了源病例。在 5 起事件中，无法确定受感染病例或传播链。5 起事件符合我们关于性传播（男传女）的标准。一起 VPDTe 事件至少导致了 4 代病例；其他事件发生后，传播受到限制。VPDTe 增加了埃博拉幸存者服务以及在以前广泛传播地区的持续监测和应对能力的重要性。
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本文引用的文献
1
Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report.
Lancet Infect Dis. 2018 Sep;18(9):1015-1024. doi: 10.1016/S1473-3099(18)30417-1. Epub 2018 Jul 23.
2
Ebola Virus Ribonucleic Acid Detection in Semen More Than Two Years After Resolution of Acute Ebola Virus Infection.
Open Forum Infect Dis. 2017 Jul 22;4(3):ofx155. doi: 10.1093/ofid/ofx155. eCollection 2017 Summer.
3
Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases.
Virus Evol. 2016 Jun 22;2(1):vew016. doi: 10.1093/ve/vew016. eCollection 2016 Jan.
4
Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child.
Clin Infect Dis. 2017 Feb 15;64(4):513-516. doi: 10.1093/cid/ciw793.
5
Unusual Ebola Virus Chain of Transmission, Conakry, Guinea, 2014-2015.
Emerg Infect Dis. 2016 Dec;22(12):2149-2152. doi: 10.3201/eid2212.160847.
6
Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days.
Clin Infect Dis. 2016 Nov 15;63(10):1353-1356. doi: 10.1093/cid/ciw601. Epub 2016 Sep 1.
7
Notes from The Field: Ebola Virus Disease Cluster - Northern Sierra Leone, January 2016.
MMWR Morb Mortal Wkly Rep. 2016 Jul 8;65(26):681-2. doi: 10.15585/mmwr.mm6526a4.
8
Reduced evolutionary rate in reemerged Ebola virus transmission chains.
Sci Adv. 2016 Apr 29;2(4):e1600378. doi: 10.1126/sciadv.1600378. eCollection 2016 Apr.
9
Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations.
BMJ Open. 2016 Jan 7;6(1):e008859. doi: 10.1136/bmjopen-2015-008859.
10
Duration of Ebola virus RNA persistence in semen of survivors: population-level estimates and projections.
Euro Surveill. 2015;20(48):30083. doi: 10.2807/1560-7917.ES.2015.20.48.30083.
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