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埃博拉病毒传播由 2014-2016 年西非疫情中持续感染的幸存者引起。

Ebola Virus Transmission Caused by Persistently Infected Survivors of the 2014-2016 Outbreak in West Africa.

机构信息

Sciensano, Brussels, Belgium.

World Health Organization Country Office, Conakry, Guinea.

出版信息

J Infect Dis. 2018 Nov 22;218(suppl_5):S287-S291. doi: 10.1093/infdis/jiy280.

DOI:10.1093/infdis/jiy280
PMID:29920602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6249578/
Abstract

The 2014-2016 Ebola virus (EBOV) disease outbreak affected over 29000 people and left behind the biggest cohort (over 17000 individuals) of Ebola survivors in history. Although the persistence of EBOV in body fluids of survivors was reported before the recent outbreak, new evidence revealed that the virus can be detected up to 18 months in the semen, which represents the biggest risk of Ebola resurgence in affected communities. In this study, we review the knowledge on the Ebola flare-ups that occurred after the peak of the 2014-2016 Ebola epidemic in West Africa.

摘要

2014-2016 年埃博拉病毒(EBOV)疾病爆发影响了超过 29000 人,并留下了历史上最大的埃博拉幸存者队列(超过 17000 人)。尽管在最近的疫情爆发之前就有报道称,幸存者的体液中仍存在埃博拉病毒,但新的证据显示,该病毒在精液中可被检测到长达 18 个月,这代表着受影响社区中埃博拉病毒死灰复燃的最大风险。在这项研究中,我们回顾了 2014-2016 年西非埃博拉疫情高峰过后发生的埃博拉病毒爆发的相关知识。

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Ebola Virus Transmission Caused by Persistently Infected Survivors of the 2014-2016 Outbreak in West Africa.埃博拉病毒传播由 2014-2016 年西非疫情中持续感染的幸存者引起。
J Infect Dis. 2018 Nov 22;218(suppl_5):S287-S291. doi: 10.1093/infdis/jiy280.
2
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本文引用的文献

1
Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors.埃博拉病毒幸存者体内的活跃复制和异质进化速率。
Cell Rep. 2018 Jan 30;22(5):1159-1168. doi: 10.1016/j.celrep.2018.01.008.
2
Sex practices and awareness of Ebola virus disease among male survivors and their partners in Guinea.几内亚男性埃博拉病毒病幸存者及其伴侣的性行为与埃博拉病毒病认知情况
BMJ Glob Health. 2017 Sep 25;2(3):e000412. doi: 10.1136/bmjgh-2017-000412. eCollection 2017.
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Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases.对塞拉利昂埃博拉病毒的快速疫情测序确定了与散发病例相关的传播链。
Virus Evol. 2016 Jun 22;2(1):vew016. doi: 10.1093/ve/vew016. eCollection 2016 Jan.
4
Lessons learned by surveillance during the tail-end of the Ebola outbreak in Guinea, June-October 2015: a case series.2015年6月至10月几内亚埃博拉疫情末期监测所得经验:病例系列
BMC Infect Dis. 2017 Apr 24;17(1):304. doi: 10.1186/s12879-017-2405-x.
5
Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea.埃博拉病毒 RNA 在精液中持续存在的动力学:来自几内亚 Postebogui 队列的报告。
Clin Infect Dis. 2017 Jun 15;64(12):1788-1790. doi: 10.1093/cid/cix210.
6
Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus.塞拉利昂埃博拉疫情感染家庭中的无症状感染和未被识别的埃博拉病毒病:一项使用新型埃博拉病毒抗体非侵入性检测方法的横断面研究
Lancet Infect Dis. 2017 Jun;17(6):645-653. doi: 10.1016/S1473-3099(17)30111-1. Epub 2017 Feb 28.
7
Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study.埃博拉病毒病幸存者精液中埃博拉病毒 RNA 的持续存在和清除:纵向分析和建模研究。
Lancet Glob Health. 2017 Jan;5(1):e80-e88. doi: 10.1016/S2214-109X(16)30243-1.
8
Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child.在无疾病报告情况下埃博拉病毒在母乳中的持续存在:母婴间病毒传播的一个可能来源
Clin Infect Dis. 2017 Feb 15;64(4):513-516. doi: 10.1093/cid/ciw793.
9
Unusual Ebola Virus Chain of Transmission, Conakry, Guinea, 2014-2015.2014 - 2015年,几内亚科纳克里埃博拉病毒不同寻常的传播链
Emerg Infect Dis. 2016 Dec;22(12):2149-2152. doi: 10.3201/eid2212.160847.
10
Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data.通过为幸存者提供国家精液检测和咨询方案预防利比里亚埃博拉病毒的性传播:埃博拉病毒 RNA 结果和行为数据的分析。
Lancet Glob Health. 2016 Oct;4(10):e736-43. doi: 10.1016/S2214-109X(16)30175-9. Epub 2016 Aug 30.