Department of Chemistry, Au×ilium College (Autonomous), Vellore 632006, India.
Department of Chemistry, C. Abdul Hakeem College, Melvisharam 632509, India.
J Nanosci Nanotechnol. 2019 May 1;19(5):2493-2500. doi: 10.1166/jnn.2019.16022.
Sodium Alginate/Poly(vinyl alcohol) (SA/PVA) blend scaffolds were successfully prepared via solution casting method for controlled release of ciprofloxacin (CPF). The structures of the films were evaluated by ATR-FTIR, XRD and SEM. A wide variety of material characteristics for the SA/PVA blend scaffolds were investigated, including the swelling behaviour, liquid displacement method, mechanical property and antibacterial activity. ATR-FTIR studies evaluated the chemical interaction between the biopolymeric scaffolds and the drug. XRD studies proved the amorphous behaviour of the prepared scaffolds. SEM images revealed good cohesivity and compatibility between the biopolymers and the cargos. SA/PVA loaded with ciprofloxacin showed maximum swelling percentage, porosity and tensile strength. The formulated ciprofloxacin loaded SA/PVA scaffold showed strong antibacterial activity. The results of CPF release from biopolymeric scaffolds at pH 1.2, 5.3 and 7.4 indicated strong pH dependence. drug-controlled release studies showed a slower and more continuous release for the SA/PVA in comparison with plain SA and PVA and the drug-delivery cumulative release was proportional to the amount and the interlayer distance of SA/PVA blend scaffolds. A sustained drug release pattern was observed with a non fickian diffusion mechanism.
海藻酸钠/聚乙烯醇（SA/PVA）共混支架通过溶液浇铸法成功制备，用于控制环丙沙星（CPF）的释放。通过衰减全反射傅里叶变换红外光谱（ATR-FTIR）、X 射线衍射（XRD）和扫描电子显微镜（SEM）对薄膜的结构进行了评估。研究了 SA/PVA 共混支架的多种材料特性，包括溶胀行为、液体置换法、力学性能和抗菌活性。ATR-FTIR 研究评估了生物高分子支架与药物之间的化学相互作用。XRD 研究证明了所制备支架的无定形行为。SEM 图像显示了生物聚合物和载药之间良好的内聚性和相容性。载有环丙沙星的 SA/PVA 显示出最大的溶胀率、孔隙率和拉伸强度。载有环丙沙星的配方 SA/PVA 支架表现出很强的抗菌活性。在 pH 值为 1.2、5.3 和 7.4 时，从生物聚合物支架中释放 CPF 的结果表明其具有很强的 pH 依赖性。药物控制释放研究表明，与普通的 SA 和 PVA 相比，SA/PVA 具有更慢、更持续的药物释放，药物传递累积释放与 SA/PVA 共混支架的数量和层间距离成正比。观察到具有非菲克扩散机制的持续药物释放模式。
