Lai Wing-Fu, Tang Ryan, Wong Wing-Tak
School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China.
School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China.
Pharmaceutics. 2020 Aug 2;12(8):725. doi: 10.3390/pharmaceutics12080725.
Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases.
皮肤是药物给药的一个有吸引力的部位，部分原因是它易于接近，并且与其他一些常见给药途径相比具有良好的特性（例如，侵入性较小和患者依从性高）。尽管如此，透皮给药的效率在很大程度上受到皮肤渗透性差的限制。为了解决这个问题，本研究报告了含油酸囊泡的产生，其可以提高药物递送效率，同时显示出良好的稳定性和有限的皮肤破坏。在被加载到复合凝胶中时，结合聚合物共混技术，报道了一种具有可调2,3,5,4'-四羟基二苯乙烯2-O-β-D-葡萄糖苷透皮通量的递送系统。考虑到良好的生物相容性和可调的递送性能，我们的系统值得进一步开发和优化，以便未来在皮肤病治疗中应用。
