阿尔茨海默病治疗的新方法。
New approaches for the treatment of Alzheimer's disease.
机构信息
Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.
Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK.
出版信息
Bioorg Med Chem Lett. 2019 Jan 15;29(2):125-133. doi: 10.1016/j.bmcl.2018.11.034. Epub 2018 Nov 19.
Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current approved therapies are symptomatic treatments having some effect on cognitive function. Therapies that target β-amyloid (Aβ) have been the focus of efforts to develop a disease modification treatment for AD but these approaches have failed to show any clinical benefit so far. Beyond the 'Aβ hypothesis', there are a number of newer approaches to treat AD with neuroinflammation emerging as a very active area of research based on risk gene analysis. This short review will summarize approved drug therapies, recent clinical trials and new approaches for the treatment of AD.
阿尔茨海默病（AD）是最常见的慢性神经退行性疾病。目前批准的治疗方法是对症治疗，对认知功能有一定的影响。针对β-淀粉样蛋白（Aβ）的治疗方法一直是开发 AD 疾病修饰治疗的重点，但迄今为止，这些方法都没有显示出任何临床益处。除了“Aβ假说”之外，还有许多新的方法来治疗 AD，神经炎症作为基于风险基因分析的一个非常活跃的研究领域正在出现。这篇简短的综述将总结 AD 的批准药物治疗、最近的临床试验和新的治疗方法。
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