Huang Sheng-Yao, Wu Meng-Ting, Sun Chung-Fu, Yang Feng-Yi
Department of Mathematics, Soochow University, Taipei 111, Taiwan.
Division of Neurosurgery, Cheng Hsin General Hospital, Taipei 111, Taiwan.
Diagnostics (Basel). 2025 Feb 4;15(3):359. doi: 10.3390/diagnostics15030359.
: Alzheimer's disease (AD) is characterized by progressive brain atrophy marked by cognitive decline and memory loss, which significantly affect patients' quality of life. Transcranial ultrasound stimulation (TUS) is a potential physical treatment for AD patients. However, the specific brain regions stimulated by TUS and its therapeutic effects remain unclear. : In this study, magnetic resonance imaging (MRI) and FreeSurfer segmentation were employed to assess alterations in the brain volume of AD patients after TUS. : Our findings revealed significant volume increases in the corpus callosum (CC) and lateral orbitofrontal cortex (lOFC) in the TUS group. Moreover, the volumetric changes in the CC were strongly correlated with improvements in the Mini-Mental State Examination score, which is a widely used measure of cognitive function of AD patients. : TUS has the potential to alleviate disease progression and offers a non-invasive therapeutic approach to the improvement of cognitive function in AD patients.
阿尔茨海默病（AD）的特征是进行性脑萎缩，表现为认知能力下降和记忆丧失，这严重影响患者的生活质量。经颅超声刺激（TUS）是一种针对AD患者的潜在物理治疗方法。然而，TUS刺激的具体脑区及其治疗效果仍不清楚。：在本研究中，采用磁共振成像（MRI）和FreeSurfer分割技术来评估TUS治疗后AD患者脑容量的变化。：我们的研究结果显示，TUS组的胼胝体（CC）和外侧眶额皮质（lOFC）的体积显著增加。此外，CC的体积变化与简易精神状态检查表评分的改善密切相关，该检查表是广泛用于衡量AD患者认知功能的指标。：TUS有减轻疾病进展的潜力，并为改善AD患者的认知功能提供了一种非侵入性治疗方法。
