Department of clinical laboratory, Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe road, Guangzhou, Guangdong, PR China.
Department of clinical laboratory, Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe road, Guangzhou, Guangdong, PR China.
Clin Res Hepatol Gastroenterol. 2019 Jun;43(3):266-272. doi: 10.1016/j.clinre.2018.10.010. Epub 2018 Nov 28.
To evaluate the reliability and accuracy of Cytokeratin-19-fragment (CYFRA21-1) in the diagnosis of intrahepatic cholangiocarcinoma (ICC) based on literature meta-analysis and the diagnostic efficacy and clinical application of CYFRA21-1 in ICC.
MEDLINE, China National Knowledge Infrastructure Library and other databases were used to base the inclusion and exclusion criteria. In addition, relevant data from studies on CYFRA21-1 were used to diagnose ICC individually or in combination was retrieved for meta-analysis. Research papers were manually screened by two independent researchers. The selected papers were evaluated by QUADAS-2 standard. The SROC was plotted according to the extracted data combined with the results of diagnosis to evaluate the diagnostic efficiency of CYFRA21-1 in ICC.
Six articles with an overall sample size of 731 cases, including 217 cases in the positive group and 514 cases in the control group, met the inclusion criteria and were included for the systematic review. When CYFRA21-1 was used for ICC diagnosis, the pooled diagnostic indices were as follows: sensitivity 0.81 (95%CI: 0.75-0.86); specificity, 0.86 (95%CI: 0.82-0.89); positive likelihood rate, 4.72 (95%CI: 2.02-11.02); negative likelihood ratio, 0.25 (95%CI: 0.19-0.33); diagnostic odds ratio, 27.43 (95%CI: 13.20-57.00); and area under the ROC curve, 0.904 (SE = 0.0171).
CYFRA21-1 is of certain value in the diagnosis of intrahepatic cholangiocarcinoma.
通过文献荟萃分析评估细胞角蛋白 19 片段（CYFRA21-1）在肝内胆管癌（ICC）诊断中的可靠性和准确性，并对 CYFRA21-1 对 ICC 的诊断效能和临床应用进行综述。
检索 MEDLINE、中国知网等数据库，根据纳入和排除标准进行筛选。此外，还检索了关于 CYFRA21-1 单独或联合诊断 ICC 的相关研究数据进行荟萃分析。由两名独立研究者手动筛选研究论文。采用 QUADAS-2 标准评估所选论文。根据提取的数据绘制 SROC 曲线，结合诊断结果评估 CYFRA21-1 对 ICC 的诊断效能。
共纳入 6 篇文献，总样本量为 731 例，其中阳性组 217 例，对照组 514 例。当使用 CYFRA21-1 诊断 ICC 时，汇总的诊断指标如下：敏感度 0.81（95%CI：0.75-0.86）；特异度，0.86（95%CI：0.82-0.89）；阳性似然比，4.72（95%CI：2.02-11.02）；阴性似然比，0.25（95%CI：0.19-0.33）；诊断比值比，27.43（95%CI：13.20-57.00）；ROC 曲线下面积，0.904（SE=0.0171）。
CYFRA21-1 对肝内胆管癌的诊断具有一定价值。
