Department of Psychiatry, University of Cambridge, and Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK.
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, UL, USA.
Psychiatry Res. 2019 Jan;271:253-258. doi: 10.1016/j.psychres.2018.11.059. Epub 2018 Nov 27.
Impulsive and compulsive symptoms often become apparent during young adulthood, which is a critical time for brain development and establishment of life goals. The aim of this study was to identify important associations with quality of life in young adults, across a range of clinical, questionnaire, and cognitive measures, focusing on impulsivity and compulsivity. Significant relationships between exploratory variables and quality of life were identified using Partial Least Squares (PLS). In the 479 participants (mean age 22.3 [SD 3.6] years), quality of life was best explained by a one-factor model (p < 0.001). Variables significantly associated with lower quality of life were: older age, greater alcohol consumption, and the presence of impulse control disorders (including gambling, compulsive buying, intermittent explosive disorder, compulsive sexual behavior, binge-eating, and skin picking), mood/anxiety disorders, post-traumatic stress disorder, and substance use disorder. Worse quality of life was also significantly explained by higher impulsiveness on the Barratt scale, and by relative impairments in extra-dimensional set-shifting and quality of decision-making. These findings suggest that impulse disorders merit more public health attention, especially problematic gambling. Performance on decision-making and set-shifting tasks also appears particularly important in understanding quality of life in young adults.
冲动和强迫症状在青年期变得明显,这是大脑发育和确立生活目标的关键时期。本研究旨在确定与年轻人生活质量相关的重要因素,包括一系列临床、问卷调查和认知测量,重点关注冲动和强迫。使用偏最小二乘法(PLS)确定探索性变量与生活质量之间的显著关系。在 479 名参与者(平均年龄 22.3 [3.6] 岁)中,生活质量最好由单因素模型解释(p < 0.001)。与生活质量较低显著相关的变量是:年龄较大、饮酒量增加以及存在冲动控制障碍(包括赌博、强迫性购物、间歇性爆发障碍、强迫性行为、暴食和皮肤搔抓)、情绪/焦虑障碍、创伤后应激障碍和物质使用障碍。巴雷特量表上的冲动性越高,多维定势转移和决策质量的相对损伤越严重,生活质量也显著降低。这些发现表明,冲动障碍值得引起更多的公共卫生关注,特别是有问题的赌博。决策和定势转移任务的表现似乎在理解年轻人的生活质量方面也特别重要。