Department of mental disorders, Norwegian Institute of Public Health, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
BMC Psychiatry. 2018 Mar 12;18(1):65. doi: 10.1186/s12888-018-1647-5.
Mental disorders often have onset early in life, contribute substantially to the global disease burden, and may interfere with young people's ability to complete age-relevant tasks in important developmental periods. However, knowledge about prevalence and course of mental disorders in young adulthood is sparse. The aim of the current study was to estimate prevalence and stability of mental disorders from the twenties to the thirties/forties.
DSM-IV mental disorders were assessed with the Composite International Diagnostic Interview in two waves (1999-2004 and 2010-2011) in 1623 young adult Norwegian twins (63.2% women, aged 19-29 years in wave 1).
In wave 1, the 12-month prevalence of any mental disorder among people in the twenties was 19.8% (men) and 32.4% (women), anxiety disorders: 9.6% (men) and 26.7% (women), anxiety disorders excluding specific phobias: 2.5% (men) and 6.9% (women), major depressive disorder (MDD): 4.4% (men) and 7.2% (women), and alcohol use disorder (AUD): 8.7% (men) and 4.4% (women). The prevalence of any mental disorder decreased from the twenties to the thirties/forties. This was due to a decrease in AUD and specific phobias. Anxiety disorders in the twenties predicted anxiety disorders and MDD ten years later, even when controlling for the association between these disorders in the twenties. MDD in the twenties predicted MDD ten years later. At both ages, two-week and 12-month prevalence estimates differed markedly for MDD - indicating an episodic course.
Common mental disorders are highly prevalent among young adults in the twenties, and somewhat less prevalent in the thirties/forties. Those who suffer from one mental disorder in the twenties are at considerably increased risk for suffering from a disorder ten years later as well. This may have significant implications for young people's ability to attain education, establish a family, and participate in occupational life.
精神障碍通常在生命早期发病,对全球疾病负担有重大影响,并且可能会干扰年轻人在重要发育阶段完成与年龄相关任务的能力。然而,关于年轻人精神障碍的患病率和病程知之甚少。本研究的目的是估计从二十多岁到三十多岁/四十多岁期间精神障碍的患病率和稳定性。
使用复合国际诊断访谈(Composite International Diagnostic Interview)在两个时间点(1999-2004 年和 2010-2011 年)对 1623 名挪威年轻成年双胞胎(女性占 63.2%,年龄为 19-29 岁)进行 DSM-IV 精神障碍评估。
在第一波中,二十多岁人群中任何精神障碍的 12 个月患病率为 19.8%(男性)和 32.4%(女性),焦虑症:9.6%(男性)和 26.7%(女性),排除特定恐惧症的焦虑症:2.5%(男性)和 6.9%(女性),重度抑郁症(MDD):4.4%(男性)和 7.2%(女性),以及酒精使用障碍(AUD):8.7%(男性)和 4.4%(女性)。从二十多岁到三十多岁/四十多岁,任何精神障碍的患病率都有所下降。这是由于 AUD 和特定恐惧症的减少。二十多岁时的焦虑症预测了十年后仍会出现焦虑症和 MDD,即使控制了这两种疾病在二十多岁时的关联。二十多岁时的 MDD 预测了十年后仍会出现 MDD。在这两个年龄段,MDD 的两周和 12 个月的患病率估计值差异显著,表明存在发作性病程。
在二十多岁的年轻人中,常见的精神障碍患病率很高,而在三十多岁/四十多岁时则略低。那些在二十多岁时患有一种精神障碍的人,十年后患有一种疾病的风险显著增加。这可能对年轻人获得教育、建立家庭和参与职业生活的能力产生重大影响。