2959 Estate View Ct, Dacula, GA 30019, USA.
Environ Res. 2019 Feb;169:342-347. doi: 10.1016/j.envres.2018.11.037. Epub 2018 Nov 23.
Impact of co-exposures to toxic metals cadmium, lead, and mercury along with perfluoroalkyl substances on the healthy kidney function was evaluated among US adults aged > = 20 years by analyzing data (N = 7857) from National Health and Nutrition Examination Survey for 2003-2014. Perfluoroalkyl substances selected for analysis were: perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA). High levels of exposures to Cd, Pb, total Hg, and PFAS were said to occur if their observed levels in blood/serum were greater than 75th percentiles. A healthy kidney function was defined if estimated glomerular filtration rate was found to be > = 60 mL/min/1.73 m and urine albumin creatinine ratio was ≤ 30 mg/g creatinine. Adjusted odds of a healthy kidney function due to co-exposures to high levels of Cd along with high levels of PFOA, PFOS, and PFNA were found to be 0.713, 0.576, and 0.640 respectively. Adjusted odds of a healthy kidney function due to co-exposures to high levels of Pb along with high levels of PFOA, and PFNA were found to be 0.657, and 0.671 respectively. Co-exposures to high levels of Hg as measured by the total mercury in blood was not found to affect the odds of a healthy kidney function.
本研究分析了 2003-2014 年美国国家健康和营养调查（National Health and Nutrition Examination Survey）的数据（N=7857），评估了 US 成年人中同时接触有毒金属镉、铅和汞以及全氟烷基物质（perfluoroalkyl substances，PFAS）对健康肾脏功能的影响。选择用于分析的全氟烷基物质有：全氟辛酸（perfluorooctanoic acid，PFOA）、全氟辛烷磺酸（perfluorooctane sulfonate，PFOS）、全氟己烷磺酸（perfluorohexane sulfonate，PFHxS）和全氟壬酸（perfluorononanoic acid，PFNA）。如果血液/血清中观察到的镉（Cd）、铅（Pb）、总汞（total Hg）和 PFAS 水平高于第 75 百分位数，则认为存在高水平暴露。如果估算肾小球滤过率（estimated glomerular filtration rate，eGFR）大于等于 60 mL/min/1.73 m，尿白蛋白与肌酐比值（urine albumin creatinine ratio，UACR）小于等于 30 mg/g 肌酐，则认为肾脏功能健康。由于同时接触高水平的 Cd 与高水平的 PFOA、PFOS 和 PFNA，健康肾脏功能的调整比值比（odds ratio，OR）分别为 0.713、0.576 和 0.640。由于同时接触高水平的 Pb 与高水平的 PFOA 和 PFNA，健康肾脏功能的调整 OR 分别为 0.657 和 0.671。然而，血液中总汞（total mercury in blood）水平的 co-exposures 并未发现对健康肾脏功能的几率有影响。
