比较近交系和杂交系小鼠之间的表型变异。
Comparing phenotypic variation between inbred and outbred mice.
机构信息
UNC Neuroscience Centre, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The Jackson Laboratory, Bar Harbor, ME, USA.
出版信息
Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7.
Abstract
Inbred mice are preferred over outbred mice with the assumption that they display less trait variability. We compared coefficients of variation and failed to find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice may be better subjects for most biomedical research.
摘要
同窝系小鼠比远交系小鼠更受欢迎，因为人们认为前者的表型变异性更小。我们比较了变异系数，并未发现同窝系小鼠的表型稳定性更高的证据。我们的结论是，与传统观点相反，远交系小鼠可能更适合大多数生物医学研究。
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