Torabi Hamidreza, Jadidi Khosrow, Naderi Mostafa
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Oman J Ophthalmol. 2018 Sep-Dec;11(3):277-279. doi: 10.4103/ojo.OJO_33_2017.
This report describes a lamellar macular hole formation subsequent to intravitreal bevacizumab injection for the treatment of choroidal neovascularization (CNV) by age-related macular degeneration. A 67-year-old woman with bilateral CNV underwent 3 monthly intravitreal bevacizumab injections in her both eyes. One month after the third bilateral injection, vision loss happened. Optical coherence tomography performed for further evaluation that showed reduction of intra- and sub-retinal fluid associated with lamellar macular hole development in both eyes. Although macular hole formation, especially bilateral form, is a rare complication of intravitreal injections, surgeons should consider macular hole development in cases with vision deterioration following intravitreal bevacizumab injection.
本报告描述了在玻璃体腔内注射贝伐单抗治疗年龄相关性黄斑变性所致脉络膜新生血管（CNV）后发生的板层黄斑裂孔形成。一名患有双侧CNV的67岁女性双眼每月接受3次玻璃体腔内贝伐单抗注射。第三次双侧注射后1个月，出现视力丧失。进行光学相干断层扫描以进一步评估，结果显示双眼视网膜内和视网膜下液减少，伴有板层黄斑裂孔形成。尽管黄斑裂孔形成，尤其是双侧性黄斑裂孔，是玻璃体腔内注射的一种罕见并发症，但在玻璃体腔内注射贝伐单抗后视力恶化的病例中，外科医生应考虑黄斑裂孔的发生。
