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资源匮乏地区急诊剖腹手术的结果评估及相关因素。病例系列研究。

Outcome assessment of emergency laparotomies and associated factors in low resource setting. A case series.

作者信息

Gebremedhn Endale Gebreegziabher, Agegnehu Abatneh Feleke, Anderson Bernard Bradley

机构信息

Department of Anaesthesia, School of Medicine, Gondar College of Medicine and Health Sciences, The University of Gondar, Gondar, Ethiopia.

Department of Surgery, School of Medicine, Gondar College of Medicine and Health Sciences, The University of Gondar, Gondar, Ethiopia.

出版信息

Ann Med Surg (Lond). 2018 Sep 25;36:178-184. doi: 10.1016/j.amsu.2018.09.029. eCollection 2018 Dec.

Abstract

BACKGROUND

Emergency laparotomy is a high risk procedure which is demonstrated by high morbidity and mortality. However, the problem is tremendous in resource limited settings and there is limited data on patient outcome. We aimed to assess postoperative patient outcome after emergency laparotomy and associated factors.

METHODS

An observational study was conducted in our hospital from March 11- June 30, 2015 using emergency laparotomy network tool. All consecutive surgical patients who underwent emergency laparotomy were included. Binary and multiple logistic regressions were employed using adjusted odds ratios and 95% CI, and P-value < 0.05 was considered to be statistically significant.

RESULT

A total of 260 patients were included in the study. The majority of patients had late presentation (>6hrs) to the hospital after the onset of symptoms of the diseases and surgical intervention after hospital admission. The incidences of postoperative morbidity and mortality were 39.2% and 3.5% respectively. Factors associated with postoperative morbidity were preoperative co-morbidity (AOR = 0.383, CI = 0.156-0.939) and bowel resection (AOR = 0.232, CI = 0.091-0.591). Factors associated with postoperative mortality were anesthetists' preoperative opinion on postoperative patient outcome (AOR = 0.067, CI = 0.008-0.564), level of consciousness during recovery from anaesthesia (AOR = 0.114, CI = 0.021-10.628) and any re-intervention within 30 days after primary operation (AOR = 0.083, CI = 0.009-0.750).

CONCLUSION AND RECOMMENDATION

The incidence of postoperative morbidity and mortality after emergency laparotomy were high. We recommend preoperative optimization, early surgical intervention, and involvement of senior professionals during operation in these risky surgical patients. Also, we recommend the use of WHO or equivalent Surgical Safety Checklist and establishment of perioperative patient care bundle including surgical ICU and radiology investigation modalities such as CT scan.

摘要

背景

急诊剖腹手术是一种高风险手术,其高发病率和死亡率已得到证实。然而,在资源有限的环境中,这个问题非常严重,而且关于患者预后的数据有限。我们旨在评估急诊剖腹手术后的患者预后及相关因素。

方法

2015年3月11日至6月30日在我院使用急诊剖腹手术网络工具进行了一项观察性研究。纳入所有接受急诊剖腹手术的连续手术患者。采用二元和多元逻辑回归分析,计算调整后的比值比和95%可信区间,P值<0.05被认为具有统计学意义。

结果

本研究共纳入260例患者。大多数患者在疾病症状出现后较晚(>6小时)才到医院就诊,且入院后才进行手术干预。术后发病率和死亡率分别为39.2%和3.5%。与术后发病相关的因素有术前合并症(比值比=0.383,可信区间=0.156-0.939)和肠切除(比值比=0.232,可信区间=0.091-0.591)。与术后死亡相关的因素有麻醉医生术前对患者术后预后的评估(比值比=0.067,可信区间=0.008-0.564)、麻醉恢复期间的意识水平(比值比=0.114,可信区间=0.021-10.628)以及初次手术后30天内的任何再次干预(比值比=0.083,可信区间=0.009-0.750)。

结论与建议

急诊剖腹手术后的发病率和死亡率较高。我们建议对这些高风险手术患者进行术前优化、早期手术干预,并在手术过程中让资深专业人员参与。此外,我们建议使用世界卫生组织或等效的手术安全检查表,并建立围手术期患者护理套餐,包括外科重症监护病房以及CT扫描等放射学检查方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/766c/6249396/3c7dd848092e/gr1.jpg

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